| 魏方超1,2 杜娟2 未宁宁3 王岩4 李尚伟2△.斑蝥素及其衍生物的研究现状与应用[J].现代生物医学进展英文版,2012,12(8):1586-1589. |
| 斑蝥素及其衍生物的研究现状与应用 |
| Progress and Application of Cantharidin and Its Derivatives |
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| DOI： |
| 中文关键词: 斑蝥素 衍生物 抗肿瘤 细胞凋亡 |
| 英文关键词: Cantharidin Analogue Antitumor Apoptosis |
| 基金项目: |
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| 中文摘要: |
| 斑蝥素(Cantharidin)是一种可从昆虫斑蝥虫体提取或人工合成的具有抗肿瘤作用的药物，因其毒性强烈，受限于临床应用。
人工合成的斑蝥素衍生物如去甲斑蝥素、斑蝥酸钠、去甲斑蝥酸钠、甲基斑蝥胺等，毒性低，疗效显著。本文对斑蝥素及其衍生物
在抗肿瘤作用及分子机理方面的研究现状进行综述，为充分利用斑蝥素这一中药资源提供参考。 |
| 英文摘要: |
| Cantharidin is an antineoplastic drug that can be extracted from cantharis or artificially synthesized. However, clinical
application of cantharidin is limited because of its strong toxicity. Synthetic cantharidin derivatives such as norcantharidin, sodium
cantharidate, sodium demethylcantharidate and methylcantharidinimide, have notable curative effects with low toxicity. In this paper,
research progress on the antitumor activities and molecular mechanisms of cantharidin and its derivatives was summarized, in order to
make full use of the traditional Chinese medicine resources. |
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