| 汪俊汉1 李臣鸿2.认识Munc13*[J].现代生物医学进展英文版,2012,12(8):1563-1565. |
| 认识Munc13* |
| Approaching Munc13* |
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| DOI： |
| 中文关键词: Munc13 结构域 功能 |
| 英文关键词: Munc13 Domain Function |
| 基金项目: |
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| 中文摘要: |
| Munc13 是C. elegans Unc-13 和Drosophila Dunc-13 在哺乳动物中的同系物,有四种亚型,是SNARE 蛋白的调节蛋白之一。
Munc13 蛋白含有两个结构域：C1 和C2 结构域，DAG/ 佛波醇结合到C1 结构域上，能增强Munc13-1 促进囊泡成熟的能力。在神
经递质的胞吐过程中，有许许多多的蛋白参与，其中Munc, Synaptotagmin 和Rab 等蛋白家族是其重要的调节因子。同时，囊泡的
转运和分泌也需要这些功能特殊的蛋白质的参与。全面了解Munc13 的结构域与功能及其在分泌中的地位和分泌模式，有助于其
在临床医学中的应用，如其在胰岛素释放等分泌调节中起着的重要作用。 |
| 英文摘要: |
| Munc13 proteins constitute a family of 4 mammalian homologue of C.elegans Unc-13 and drosophila Dunc-13, which
is one of the regulation proteins of SNARE protein. Munc13 proteins contain C1 domain and C2 domain. The binding of DAG/phorbol-ester
to C1 domain leads to enhanced priming activity ofMunc13-1. Many proteins participated in the process of synaptic transmission such
as Munc, Synaptotagmin and Rab. Meanwhile, these critical proteins are involved in the process of vesicle translocation and secretion. It
will help to know the application in clinical medicine to understand comprehensively the domains and the functions of Munc13, such as it
plays a critical role in insulin release. |
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