| 魏红霞张葵△ 李雷顾光煜王丽倪军.血清脂联素与载脂蛋白A5 及2 型糖尿病的关系[J].现代生物医学进展英文版,2012,12(8):1498-1501. |
| 血清脂联素与载脂蛋白A5 及2 型糖尿病的关系 |
| The Relationship Among Plasma Adiponectin, Apolipoprotein A5and Type 2 Diabetic Patients |
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| DOI： |
| 中文关键词: 脂联素 载脂蛋白A5 冠心病 |
| 英文关键词: Adiponectin ApolipoproteinA5 T2DM |
| 基金项目:南京市科技发展重点项目(ZKM06055) |
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| 中文摘要: |
| 目的：检测血清脂联素(APN)水平，分析血清APN 浓度与血脂、血清载脂蛋白A5(apoA5)及2 型糖尿病的关系。方法：收集2
型糖尿病(T2DM) 210 例，健康体检者112 例，采用ELISA 法检测血浆脂联素水平，双抗体夹心ELISA 法检测血清载脂蛋白A5
(apoA5)水平，7600-020E 全自动生化分析仪检测总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固
醇(HDL-C)等，放射免疫分析仪检测血胰岛素水平。结果：T2DM 患者血清APN 浓度明显低于健康对照组，LDL-C、TG 及TC 均高
于对照组(P＜0.05)。T2DM 患者血清apoA5 浓度(200.3±51.2)ng/ml，显著低于健康对照组(229.8±56.5)ng/ml，P＜0.05。Pearson 相关
分析显示经年龄、性别校正后APN 水平与LDL-C、TG 呈负相关，与HDL-C 呈正相关；T2DM 组APN 与apoA5 呈正相关(P＜
0.05)。结论：T2DM 患者血清APN 水平显著降低，本研究证实低水平血清APN 和apoA5 不仅与血脂代谢密切相关，还可作为
T2DM 患者早期监测的指标，对其预后评价具有积极的意义。 |
| 英文摘要: |
| Objective: To test plasma adiponectin of type 2 diabetic patients (T2DM) and evaluate whether plasma adiponectin
(APN) was associated with T2DM. Methods: Plasma APN were measured using adiponectin ELISA kit in 223 cases T2DM patients and
112 cases healthy examinations, apolipoproteinA5 (apoA5) concentration were tested by sandwich enzyme-linked immunosorbent assay.
Plasma total cholesterol (TC), triglycerin (TG), low density lipoprotein cholesterol (LDL-C) and high density lipoprotein cholesterol
(HDL-C) were measured by 7600-020E automatic biochemistry analyzer, The serum insulin were measured by using RIA. Results:
Plasma APN in T2DM were significantly lower than those in the control subjects, and the level of LDL-C, TG, Lp (a) are higher than the
comparison group (P＜0.05) Serum apoA5 concentrations (200.3±52.6)ng/ml of T2DM were lower than healthy control (229.8±56.5)
ng/ml, P＜0.05. Pearson correlation analysis showed that adiponectin was significantly negatively correlated with LDL-C and TG, and
positively correlated with HDL-C after adjustment for age and sex, APN was positively correlated with apoA5 in T2DM. Conclusion:
Serum APN of T2DM patients were apparently decreased, this research lower APN and apoA5 not only correlated with lipid metolism,
but also as a early index for monitoring of T2DM patients, have active significance for Prognostic evaluation. |
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