| 杨博萍韩健△ 韩新美俞丽丽颜耀华周元国李力△.RhoB/ROCK 蛋白分子在重度子痫前期的表达[J].现代生物医学进展英文版,2012,12(8):1410-1413. |
| RhoB/ROCK 蛋白分子在重度子痫前期的表达 |
| The Expression of RhoB/ROCK Molecules in Severe Preeclampsia |
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| DOI： |
| 中文关键词: RhoB ROCK 重度子痫前期 |
| 英文关键词: RhoB ROCK Severe preeclampsia |
| 基金项目:国家自然科学基金(30901612) |
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| 中文摘要: |
| 目的：探讨RhoB/ROCK 蛋白分子在重度子痫前期（severe preeclampsia, sPE）患者胎盘组织中表达水平以及意义。方法：取
sPE 产妇和正常产妇胎盘组织各20 例,通过Western blot 和免疫组化检测胎盘组织中Rho 亚家族蛋白（RhoB、RhoC）及其Rho 激
酶即ROCK（ROCKI、ROCKII）蛋白的表达水平，应用Spearman 等级相关分析法检验RhoB、RhoC 与ROCKI、ROCKII 蛋白表达
水平的相关性。结果：RhoB、ROCKI、ROCKII 蛋白在sPE 表达水平增加（P< 0.05）；sPE 患者胎盘组织中RhoB 与ROCKI、
ROCKII 蛋白表达水平均呈正相关(r= 0.793，r= 0.901,P<0.05)。结论：RhoB 及其与下游分子ROCKI、ROCKII 构成的信号通路，
在sPE 的发病中可能发挥着重要的作用。 |
| 英文摘要: |
| Objective: To investigate the expression of RhoB and ROCK in severe preeclampsia and explore its clinical
implication. Methods: Western blotting and immunohistochemical staining methods were used to detect the expression of Rho proteins
（RhoB, RhoC）and kinase ROCK（ROCKI, ROCKII）in the placenta tissue including 20 severe preeclampsia pregnancy patients and 20
healthy pregnant women as control group. The correlation of the expression of RhoB, RhoC and ROCKI, ROCKII were analyzed
Spearman rank correlation analysis. Results: RhoB, ROCKⅠand ROCK II were more abundant in the placenta tissue of the severe preeclampsia
than in the normal placent (P<0.05). In severe preeclampsia group, the expression of RhoB and ROCKI, ROCK II had positive
relationship (r= 0.793, r=0.901, P<0.05). Conclusion: Signaling pathway constituted RhoB and its downstream molecules ROCKI, ROCK
II, may play essential role in severe preeclampsia. |
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