| 张园园肖利云伍会健△.转录辅调节因子在剪接过程中的作用[J].现代生物医学进展英文版,2012,12(7):1374-1379. |
| 转录辅调节因子在剪接过程中的作用 |
| Transcription Coregulators Moonlight as Splicing Factor |
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| DOI： |
| 中文关键词: 基因转录起始 转录辅调节因子 pre-mRNA 剪接 |
| 英文关键词: Gene transcription initiation Transcriptional coregulator Pre-mRNA splicing |
| 基金项目:辽宁省高等学校优秀人才支持计划(LR201007)；高等学校博士学科点专项科研基金(20100041110023)；
中央高校基本科研业务费专项资金(DUT10ZD113)资助课题 |
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| 中文摘要: |
| 细胞通过基因表达调控来应对外界刺激，其中对基因转录起始和pre-mRNA 剪接的调控是基因表达调控的重要环节。越来
越多的实验显示基因转录和pre-mRNA 剪接这两个过程在时空上密切相关。基因转录能调节剪接模式的选择性，反之剪接过程也
影响基因转录。近年来研究发现转录辅调节因子在联系转录和剪接过程中扮演着重要角色。转录辅调节因子对基因表达的调控
不仅在于影响转录产物的量，还可以调控pre-mRNA 的选择性剪接并产生不同的剪接体，从而翻译出具有不同生物学功能的蛋白
质。本文主要阐述了基因转录与剪接之间的关系以及它们之间相互作用的机制，有利于更深入理解基因表达调控的过程。 |
| 英文摘要: |
| The regulation of gene expression is respond to the extra stimuli signals in mammalian cells. Mostly, both gene
transcription and pre-mRNA splicing are the sticking regulation steps during gene expression. Increasing evidences showed that gene
transcription and pre-mRNA splicing are highly related with each other in both space and time. Gene transcription could affect
pre-mRNA splicing and inversely it is also regulated by pre-mRNA splicing factors. Recently, it is found that transcription coregulators
play important roles in the processes of gene expressing regulation and pre-mRNA splicing. Moreover, transcription coregulators not only
modulate the amount of transcripts but also influence the function of target protein which is coded by the splicing mature mRNA
achieved from the alternative splicing that is regulated by the coregulators during the gene expression regulation. In this review, we
mainly demonstrated the relationship between gene transcription and pre-mRNA splicing and concluded the molecular mechanism of
their interactions, which would help us to deeply understand the process of gene expression regulation. |
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