| 陈丹于壮△ 潘华政杨堃刘相萍.RalA RhoC 在非小细胞肺癌组织中的表达及意义[J].现代生物医学进展英文版,2012,12(7):1296-1299. |
| RalA RhoC 在非小细胞肺癌组织中的表达及意义 |
| The Expression and Significance of RhoC and RalAin Non-Small Cell Lung Carcinoma |
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| DOI： |
| 中文关键词: 非小细胞肺癌 RhoC RalA 荧光定量PCR |
| 英文关键词: Lung carcinoma RhoC RalA Real-Time PCR |
| 基金项目:青岛市科技计划项目（06-2-2-5-nsh-1）；山东省科技发展计划项目（2010GWZ20206） |
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| 中文摘要: |
| 目的：观察RalA 和RhoC 基因在非小细胞肺癌组织细胞中的表达变化，探讨它们的表达在非小细胞肺癌发展和侵袭转移中
的作用。方法：通过实时荧光定量PCR(FQ-PCR)检测RalA、RhoC 在60 例非小细胞肺癌患者的肿瘤组织和癌旁组织细胞中的表
达，了解其与非小细胞肺癌临床病理学指标的关系。结果：RhoC 在非小细胞肺癌组织细胞中的表达较癌旁组织显著增高(P<0．
05), 且与淋巴结的转移、TNM 分期和分化程度密切相关(P<0.05)。而RalA 在非小细胞肺癌组织细胞中的表达量低于癌旁组织
(P<0．05)，与淋巴结转移无明显相关（P>0.05）。二者在鳞、腺癌中表达均无差异（P<0.05）。结论：肺癌组织细胞中RhoC 表达升高
及RalA 表达异常下调与非小细胞肺癌的发生、发展及侵袭机制关系密切。 |
| 英文摘要: |
| Objective: To investigate the mRNA express of Ral A and RhoC in lung carcinoma and their clinical significance.
Methods: The quantity of RhoC and RalA were detected by TaqMan probe based fluorescence quantitative polymerase chain reaction
(FQ-PCR) in 60 cases of lung carcinoma,corresponding para-cancer tissues. Results: In lung carcinoma,the mean quanitities of RhoC
mRNA were higher than that in corresponding para-cancer tissues (P<0.05),and was closely related with lymph node metastases;TNM
stage and histological grade. The mean quanitities of RalA mRNA was higher in corresponding para-cancer tissues (p<0.05),and no
significant association was found bettwen RalA and lymph node metastases（P>0.05）.In lung caner,both RalA and RhoC mRNA have no
difference between squamous cell carcinoma and adenocarcinoma. Conclusion: Preserved expressin of Rho C and defective expressin of
RalA can be concerned with NSCLC. |
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