| 童颖杨甲梅△ 孙汉勇刘健.Smo 蛋白在肝癌和肝硬化中的表达及临床意义[J].现代生物医学进展英文版,2012,12(7):1208-1210. |
| Smo 蛋白在肝癌和肝硬化中的表达及临床意义 |
| Expression of Smo Protein in Hepatocellular Carcinomaand Liver Cirrhosis and its Clinical Significance |
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| DOI： |
| 中文关键词: 肝癌 Smo HE 染色 免疫组织化学 基因芯片技术 |
| 英文关键词: Hepatocellular carcinoma Smo HE staining Immunohistochemistry Gene chip technology |
| 基金项目: |
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| 中文摘要: |
| 目的：研究Smoothened（SMO）在肝癌和肝硬化中的表达及临床意义。方法：选取组织标本后，运用石蜡包埋，切片后，HE 染
色，构建组织芯片，免疫组织化学和原位杂交方法检测Smo 蛋白在肝癌和肝硬化中的表达。结果：Smo 蛋白在肝癌细胞浆、良性
肝肿瘤组织细胞浆、肝硬化组织中强染色，在正常组织中无染色。并且在典型肝硬化中强染色，在中度肝硬化中弱阳性。结论：Smo
蛋白表达与肝癌的发生有关，Smo 基因的高表达可能激活某种机制而参与诱导肝癌的发生。可能是通过异常激活Sonic hedgchog
信号通路，从而诱导肝癌的发生与发展。 |
| 英文摘要: |
| Objective: To study the expression of Smoothened ( SMO ) in hepatocellular carcinoma and liver cirrhosis and its
clinical significance. Methods: The selected tissue specimens were embedded with paraffin, and HE stained after sectioned. Constructed
tissue microarrays. Use immunohistochemistry and in situ hybridization method to detect the Smo protein expression in hepatocellular
carcinoma and liver cirrhosis. Results: Smo protein had strong staining in cytosol of hepatocellular carcinoma, benign liver tumor tissue
and liver cirrhosis tissue, but no staining in the normal tissue. And it had a strong staining in typical liver cirrhosis, and is weak positive in
moderate liver cirrhosis. Conclusion: The expression of Smo protein is related to the occurrence of hepatocellular carcinoma. The higher
expression level of Smo gene may activate a mechanism involved in the induction of hepatocellular carcinoma. It induces the occurrence
and development of hepatocellular carcinoma probably by abnormally activating the Sonic hedgchog signaling pathway. |
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