| 邓志婷戚欣李静△.创新药物体外ADMET 的高通量筛选技术研究进展[J].现代生物医学进展英文版,2012,12(6):1176-1178. |
| 创新药物体外ADMET 的高通量筛选技术研究进展 |
| High Throughput Screening of in Vitro ADMET Profiling inDrug Discovery |
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| DOI： |
| 中文关键词: 高通量筛选 理化性质 ADMET |
| 英文关键词: High throughput screening Physicochemical property ADMET |
| 基金项目:国家高技术研究发展计划(863 计划)资助项目(2007AA09Z405) |
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| 中文摘要: |
| 目前的新药研发策略已从传统的以活性为主导的筛选模式，转变为在测定药效的同时平行评价化合物的ADMET 性质，并
建立了系列体外ADMET 高通量筛选技术。本文综述了近年来药物体外ADMET 高通量筛选技术的研究进展。 |
| 英文摘要: |
| Evaluation and optimization of drug metabolism and pharmacokinetic data plays an important role in drug discovery
and development. In this review, we summarize state of the high throughput assays for screening of key physicochemical properties such
as pKa, lipophilicity and solubility as well as in vitro ADMET profiling. |
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