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目的：研究血清IL-18 与亚代谢综合症（亚MS）、代谢综合症（MS）的关系，探讨生活方式改变（TLC）后IL-18 及相关标记物的变化及其临床意义。方法：16 例对照组，14 例亚MS 组，34 例MS 组；采用自动生化仪测定空腹血脂水平；采用乳胶增强免疫比浊法检测hs-CRP 水平；采用ELISA 法检测受试者血清IL-18、IL-6 和脂联素水平。结果：MS 患者血清IL-18 水平与腰围有明显相关性（rs=0.45，P<0.01）；与亚MS 组比较，MS 组IL-18 水平显著升高（P<0.01）；与正常组比较，MS 组患者的腰围、体重指数、 hs-CRP、IL-6 及IL-18 显著升高（P<0.05）。TLC 后体重减轻5%，MS 患者IL-18、IL-6、hs-CRP 水平显著降低（P<0.01），脂联素水平显著升高（P<0.01）。结论：IL-18 可作为亚MS 和MS 预测指标，鉴别亚MS 与MS，其含量的变化对病情进展的程度及疗效的判定有重要意义。

英文摘要:

Objective: To study the relationship of serum IL-18 levels with metabolic syndrome (MS) and pre-MS, to investigate after lifestyle modification the changes of serum IL-18 levels and related biomarkers, as well as their clinic significance. Methods: Subjects were divided into control group(n=16), pre-MS group(n=14) and MS group(n=34) . The automatic biochemistry analyzer was employed to measure the fasting lipid levels. The level of serum high-sensitivity C-reactive protein was detected by immune turbidimetry. The levels of interleukin-18, IL-6 and adiponectin were detected by ELISA. Results: Levels of IL-18 were highly correlated with waist circumference (rs=0.45，P<0.01). Compared with pre-MS group, the level of IL-18 was significantly increased in MS group (P<0.01). When compared with control group, the levels of waist circumference, BMI, hs-CRP, IL-6 and IL-18 showed a significant increase in MS group. Weight loss of at least 5% caused by lifestyle modification significantly decreased the serum IL-18 concentration and levels of IL-6 and hs-CRP (P<0.01), but increased the adiponectin levels. Conclusion: IL-18 may be a useful biomarker for distinguishing MS from pre-MS subjects. The detection of IL-18 and related biomarkers could bring more instructive information in disease severity assessment and prognosis.

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