| 潘新亭王新生△ 王正滨朱青云韩燕.Smad2 与TGF-β1 基因在胰腺癌中的表达及临床意义[J].现代生物医学进展英文版,2012,12(6):1122-1125. |
| Smad2 与TGF-β1 基因在胰腺癌中的表达及临床意义 |
| Expression of Smad2 and TGF-β1 in Human Pancreatic Carcinoma Tissuesand its Signifiance* |
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| DOI： |
| 中文关键词: 胰腺癌 Smad2 TGF-β1 免疫组织化学 |
| 英文关键词: Pancreatic carcinoma Smad2 TGF-β1 Immunohistochemistry |
| 基金项目:中国博士后科学基金面上项目(2011M500697) |
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| 中文摘要: |
| 目的：通过检测Smad2 与TGF-β1 基因在胰腺癌中的表达，初步探讨它们与胰腺癌临床病理的关系。方法：采用免疫组织化
学pv-9000 法检测50 例胰腺癌组织和10 例正常胰腺组织中Smad2 与TGF-β1 的表达情况，并分析其与胰腺癌临床病理的相关
性。结果：Smad2 与TGF-β1 在胰腺癌组织中的表达水平显著高于正常胰腺组织，两组之间存在显著差异（P＜0.05）。在胰腺癌组
织中，Smad2 与TGF-β1 的表达在胰腺癌不同分期中存在显著差异（P＜0.05）。结论：Smad2 与TGF-β1 在胰腺癌中高表达，二者
联合可作为反映胰腺癌临床分期的生物学指标。 |
| 英文摘要: |
| Objective: To investigate relationships of the expression of Smad2, TGF-β1 in the tissues of pancreatic adenocarcinoma
and normal pancreas and the clinicopathological parameters of pancreatic adenocarcinomas. Methods: The expressions of the
Smad2, TGF- β1 in formalin-fixed paraffin embedded samples of 50 patients and 10 normal pancreatic tissues were detected by
pancreatic adenocarcinoma. The ages, gender, tumor size, location, degree of differentiation and stage were recorded. Results: The
expression of Smad2, TGF-β1 was higher in pancreatic adenocarcinoma than that in the normal pancreatic parenchyma. There were
significant differences between the two groups （P＜0.05）.
In pancreatic adenocarcinoma, the expression of Smad2, TGF-β1 in different
TNM staging were significantly different（P＜0.05）.
Conclusions: The expression of Smad2, TGF-β1 in pancreatic adenocarcinoma was
higher than that in the normal pancreatic parenchyma. The expression of Smad2, TGF-β1 in pancreatic cancer tissues was related to the
tumor stage. |
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