| 黎功炳1 雷宁2 龙军1 陈德书1 易伟1 龙静1△.刺五加胶囊改善抑郁大鼠学习记忆能力及对海马BDNF 表达的影响[J].现代生物医学进展英文版,2012,12(6):1078-1080. |
| 刺五加胶囊改善抑郁大鼠学习记忆能力及对海马BDNF 表达的影响 |
| The Effects of Acanthopanacis Senticosi Pill on the Expression of THand TPH in Hippocamp of Depressed Rats |
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| DOI： |
| 中文关键词: 刺五加 抑郁 EL SET BDNF |
| 英文关键词: Acanthopanacis senticosi Depression BDNF EL SET |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨刺五加胶囊对抑郁大鼠学习记忆能力及对海马BDNF 表达的影响。方法：SD 大鼠随机分为正常组、模型组和刺
五加胶囊低、中、高剂量组，21d 慢性轻度不可预见性应激刺激法（CUMS）制备大鼠抑郁模型，对照组给予生理盐水1ml 灌胃，刺
五加胶囊低、中、高剂量组分别给予刺五加胶囊(200mg/kg，400mg/kg，800mg/kg)灌胃，取大鼠海马组织。分别采用Morris 水迷宫法
和免疫组织化学法观察大鼠大鼠学习记忆能力及对海马脑源性神经生长因子（BDNF）表达。结果：刺五加胶囊低剂量组能升高海
马组织中BDNF 的表达（P<0.05, P<0.01），降低大鼠逃避潜伏期（EL）时间，提高大鼠空间探索时间(SET)（P<0.05, P<0.01）。结论：
刺五加胶囊能升高抑郁大鼠海马组织BDNF 的表达，提升抑郁大鼠学习记忆能力。 |
| 英文摘要: |
| Objective: To investigate the effects of acanthopanacis senticosi pill on the expression of BDNF in hippocamp and
learning and memory capability of depressed rats. Methods: Sprague Dawley rats were divided into normal, control and acanthopanacis
senticosi pill (200mg/kg，400 mg/kg，800 mg/kg )groups. Contents of BDNF in hippocamp were detected by immunity histochemical
method methods, The learning and memory capability of depressed rats were measured by Morris water maze. Results: In acanthopanacis
senticosi pill groups, BDNF in hippocamp and SET were increased markedly, EL were decreased markedly. Conclusion: Acanthopanacis
senticosi pill could increase the expression of BDNF in hippocamp of depressed rats. It could increase learning and memory capability of
depressed rats,too. |
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