| 王鹏1 余旻1△ 王嘉军2.基质金属蛋白酶-9 与全身炎症反应综合征研究进展[J].现代生物医学进展英文版,2012,12(5):998-1000. |
| 基质金属蛋白酶-9 与全身炎症反应综合征研究进展 |
| Progress in Correlation between Matrix Metalloproteinase - 9and Systemic Inflammation Response Syndrome |
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| DOI： |
| 中文关键词: 基质金属蛋白酶-9 全身炎症反应综合征 多器官功能障碍综合征 细胞外基质 |
| 英文关键词: Matrix metalloproteinase - 9 Systemic inflammation response syndrome Multiple organ dysfunction syndrome Extracellular matrix |
| 基金项目:湖北省自然基金资助项目（2009CDZ029） |
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| 中文摘要: |
| 全身炎症反应综合征是引发多器官功能障碍综合征的主要原因，而其发生的关键环节是血管内皮细胞的损伤。内皮细胞外
基质是内皮细胞生存的依托，其主要成分为IV 型胶原。基质金属蛋白酶-9 可以降解IV 型胶原，破坏内皮细胞外基膜。本文综述
了基质金属蛋白酶-9 与全身炎症反应的关系。 |
| 英文摘要: |
| Systemic inflammation response syndrome (SIRS) is the leading cause of multiple organ dysfunction syndrome
(MODS). The normal function of the endothelial cells depend on extracellular matrix(ECM) whose important component is the collagen
IV (IV-C). ECM could be damaged by Matrix metalloproteinase - 9 (MMP-9) for inducing the degradation of IV-C. This paper briefly
review relative reports on the correlation between MMP-9 and SIRS. |
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