| 刘董敏1 常珊1 胡建平2 田绪红1△.蛋白质- 核酸对接方法研究进展[J].现代生物医学进展英文版,2012,12(5):979-983. |
| 蛋白质- 核酸对接方法研究进展 |
| Progress in the Methods of Protein-nucleic Acid Docking |
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| DOI： |
| 中文关键词: 蛋白质- 核酸对接 构象搜索 打分函数 柔性对接 |
| 英文关键词: Protein-nuclei acid docking Conformational search Scorning function Flexible docking |
| 基金项目: |
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| 中文摘要: |
| 分子对接技术作为预测蛋白质- 核酸复合物结构的有效方法，为研究在生物学过程中蛋白质- 核酸的相互作用提供了重要
的工具。本文首先分析了当前蛋白质- 核酸对接研究中的主要困难，例如构象变化和核糖磷酸骨架的带电性问题。然后从构象搜
索、打分函数、柔性策略三个方面比较和总结了蛋白质- 核酸对接中主要的计算方法。最后回顾了蛋白质- 核酸对接计算模型的
应用，并对未来的工作进行了展望。 |
| 英文摘要: |
| As an effective approach on the prediction of protein-nucleic acid complexes structures, molecular docking technology
plays a central role in the study of protein-nucleic acid interactions during biological processes. In this article, we firstly analyzed the
main difficulties in the protein-nucleic acid docking, such as the conformational changes and the highly charged sugar-phosphate backbone.
Meanwhile, we compared and concluded the major computational methods of the conformational searching, scorning function and
flexible strategy in the protein-nucleic acid docking. Finally, the existing applications of the protein-nucleic acid docking were given and
the prospects of the future study were made. |
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