| 符春晖严华陆永光陈湘桂黄军章.肾素- 血管紧张素- 醛固酮系统与原发性高血压病的关系[J].现代生物医学进展英文版,2012,12(5):948-950. |
| 肾素- 血管紧张素- 醛固酮系统与原发性高血压病的关系 |
| The Correlation between Essential Hypertension andRenin-angiotensin-aldosterone System |
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| DOI： |
| 中文关键词: 高血压 肾素 血管紧张素Ⅱ 醛固酮 |
| 英文关键词: Hypertension Plasma renin activity AngiotensinⅡ Aldosterone |
| 基金项目:广西青年科学基金资助项目（0542070） |
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| 中文摘要: |
| 目的：探讨血浆肾素- 血管紧张素系统与原发性高血压病的关系。方法：采用病例- 对照研究设计，入选125 例原发性高血
压病患者与60 例血压正常健康体检者为对照组。采用放射免疫方法测定立位、卧位血浆肾素活性（PRA），醛固酮（ALD）浓度及血
管紧张素Ⅱ（AngⅡ）浓度。结果：原发性高血压患者，立位、卧位血浆PRA 均低于正常对照组（P＜0.05），而ALD 浓度及AngⅡ浓
度均高于正常对照组（P＜0.05）。根据高血压病1 级、2 级、3 级分组，立位、卧位血浆PRA 均依次降低（P＜0.05）；而ALD 浓度及
AngⅡ浓度依次升高（P＜0.05）。结论：肾素- 血管紧张素- 醛固酮系统与原发性高血压病的发病关系密切，血浆PRA 水平、AngⅡ
及ALD 浓度有望成为原发性高血压病分级的有效指标；降低原发性高血压患者AngⅡ及ALD 量是治疗高血压病的关键，血浆
AngII、ALD 也有望成为评价原发性高血压病疗效的指标。 |
| 英文摘要: |
| Objective: To assess the correlation between essential hypertension and renin-angiotensin-aldosterone system (RAAS)
in patients. Methods: Using a case-control study design, 125 patients with essential hypertension were compared to 60 control patients.
The plasma levels of renin activity (PRA), angiotensinⅡ (AngⅡ) and aldosterone (ALD) were measured by radioimmunoassay (RIA).
Results: The plasma levels of PRA in the hypertensive patients were significantly lower than that of the controls(P＜0.05), but the plasma
levels of AngⅡ and ALD were higher (P＜0.05). With the severity of their blood pressure, the plasma levels of PRA decreased,but the
plasma levels of AngⅡand ALD increased ,and showed statistical differences between the groups (P＜0.05). Conclusion: There was a
strong association between essential hypertension and RAAS. PRA, Ang Ⅱ and ALD hopefully served as a effective index of
hypertensive classification. The reductions of AngⅡ and ALD are critical events in the treatment of hypertension, and that maybe served
as parameters representing the therapeutic efficacy. |
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