| 王耀钟1 岳金2 贾暮云2△ 袁荣涛2 邓悦1△.VEGF-C 在口腔鳞状细胞癌中的表达及其意义[J].现代生物医学进展英文版,2012,12(5):896-899. |
| VEGF-C 在口腔鳞状细胞癌中的表达及其意义 |
| Expression and Meaning of VEGF-C in Oral Squamous Cell Carcinoma |
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| DOI： |
| 中文关键词: 血管内皮生长因子-C 口腔 肿瘤 鳞状细胞 免疫组织化学 |
| 英文关键词: Vascular endothelial growth factor C Oral Neoplasms Squamous Cell Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：检测血管内皮生长因子-C(VEGF-C)在口腔鳞状细胞癌(鳞癌)和癌旁组织中的表达情况，探讨VEGF-C 在口腔鳞癌的
增殖、浸润和淋巴转移中的作用。方法：采用免疫组化方法检测60 例口腔鳞癌病人癌组织和癌旁组织中VEGF-C 的表达，应用
图像分析系统进行分析，用Spearman 相关分析研究其与病变部位、肿瘤大小、病理分级、临床分期及颈淋巴结转移之间的关系。
结果：口腔鳞癌组织VEGF-C 的表达明显高于癌旁组织(u=7.747，P<0.01)，其表达强度与临床分期及淋巴结转移密切相关(r=0.564、
0.706，P<0.05)，与病变部位、大小、病理分级无关。结论：口腔鳞癌细胞分泌VEGF-C 诱导癌周淋巴管增生扩张是发生区域淋巴结
转移的重要因素之一，VEGF-C 有望作为早期临床判断和预测颈淋巴结转移的指标之一。 |
| 英文摘要: |
| Objective: To investigate the expression of vascular endothelial growth factor C (VEGF-C) in oral squamous cell
carcinoma (OSCC) and adjacent tissues, and to investigate the effect of the VEGF-C in the proliferation, invasion and metastasis of OSCC.
Methods: Image analysis system was used to detect the expression of VEGF-C in OSCC. Adjacent normal tissues in 60 patients were
determined by immunohistochemical staining, then the relationship with lesion, size, pathologic grade, clinical stage and neck lymph
node metastasis was analyzed. Results：There was significant difference between the OSCC and the adjacent tissues in the expression of
VEGF-C(u=7.747，P < 0. 01), which indicated there was close relation between the VEGF-C expression intensity and the proliferation，invasion
and metastasis of OSCC. Conclusion: The VEGF-C expressed by OSCC plays an important role in regional lymph node metastasis
by inducing Cancer-week lymphatic hyperplasia expansion. |
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