| 张永辉1 熊建琼1△ 唐红鹰2 张强3.噻托溴铵治疗老年稳定期COPD 临床观察[J].现代生物医学进展英文版,2012,12(5):889-891. |
| 噻托溴铵治疗老年稳定期COPD 临床观察 |
| Clinical Observation on Tiotropium Treatment of Elderly Patientswith Stable COPD |
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| DOI： |
| 中文关键词: 噻托溴铵 COPD 老年 吸烟 |
| 英文关键词: Tiotropium COPD Elderly Smoking |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨噻托溴铵吸入剂对老年吸烟稳定期慢性阻塞性肺疾病(COPD)的临床疗效。方法：入选稳定期COPD 老年患者92
例，随机分为2 组各46 例，观察组予噻托溴铵吸入剂18 微克每日一次，对照组予缓释茶碱0.1 克每12 小时口服，两组均按需使
用沙丁胺醇气雾剂，随访2 月，比较两组治疗前后的肺功能与生活质量改善情况。结果：观察组治疗后St George 评分明显下降
(P<0.01)，显著低于对照组(P<0.01)，FEV1/FVC、FEV1/Pred、FEV1 均较治疗前明显升高(P<0.01)，而对照组治疗前后无显著差异
(P>0.05)。结论：吸入噻托溴铵能显著改善老年吸烟COPD 稳定期患者的肺功能与生活质量。 |
| 英文摘要: |
| Objective: To investigate the efficacy of tiotropium inhaler in elderly smokers with stable chronic obstructive pulmonary
disease (COPD). Methods: 92 elderly patients with stable COPD were randomly divided into 2 groups with each of 46 cases. The observation
group were treated with inhaled tiotropium 18 micrograms once daily, and the control group were treated with sustained-release
theophylline 0.1 g orally every 12 hours. All patients might use salbutamol aerosol if needed, and followed up for 2 months. Lung function
and quality of life improvement were compared before and after treatment. Results: In the observation group, St George score decreased
significantly after treatment (P<0.01), significantly lower than the control group (P<0.01). FEV1/FVC, FEV1/Pred, FEV1 was significantly
higher than those before treatment (P<0.01). However, the control group showed no significant difference (P>0.05).Conclusion: Inhaled
tiotropium can significantly improve lung function and life quality of elderly smokers with stable COPD. |
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