| 吴凯1,2 高音1 陈晓平2△ 万里艳2 李龙心2 邓小明刘凯2 吕政兵2 杨芮2.脉压、脉压指数对肥胖预测的前瞻性队列研究[J].现代生物医学进展英文版,2012,12(5):880-884. |
| 脉压、脉压指数对肥胖预测的前瞻性队列研究 |
| High Pulse Pressure is Associated with Increased Risk of Obesityin Middle-aged Chinese Residents |
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| DOI： |
| 中文关键词: 体重质量指数 肥胖 脉压 脉压指数 收缩压 舒张压 患病率 |
| 英文关键词: Body mass index(BMI) Obesity Pulse pressure Pulse pressure index Systolic blood pressure Diastolic blood pressure Prevalence |
| 基金项目:国家“十一五”科技支撑项目：代谢综合征的发病趋势和综合控制研究（2006BAI01A01） |
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| 中文摘要: |
| 目的：分析成都地区1992 年时非肥胖中年居民脉压（PP）、脉压指数（PPI）对该人群15 年后（2007 年）肥胖发生的预测价值。
方法：本研究纳入1992 年时年龄处于45～60 岁且BMI 正常者1017 人，依据PP（PP≤60mmHg 及PP＞60mmHg）及PPI（PPI≤
0.450 及PPI＞0.450）分为PP/PPI 正常组及增高组，分析两组人群在15 年后（2007 年）BMI 分布特征及肥胖的患病情况。结果：①
1992 年PP/PPI 增高人群2007 年时BMI 皆高于PP/PPI 正常人群，t 检验示BMI 组间差异有统计学意义。2007 年肥胖患病率亦呈
类似BMI 的特点，亦为PP/PPI 增高组高于PP/PPI 正常组，经x2 检验，肥胖患病率的组间差异有统计学意义。② 根据该队列人群
1992 年的PP 增高与否计算2007 年的肥胖患病率的相对危险度（RR）为4.109，P 值为0.000，95%可信区间为2.874～8.847；1992
年PPI 与2007 年肥胖患病的RR 为4.998，P 值为0.000,95%可信区间为2.876～8.687。③ 使用logistic 回归模型分析1992 年基
线PP/PPI 对2007 年肥胖患病的影响，在调整了SBP、WC、BMI、HR、TG 后，PP、PPI 的相对危险度仍为1.040 及1.044。其各自相
应95%CI 分别为1.017～1.065、1.025～1.063。结论：脉压、脉压指数的异常与肥胖的发生关系密切，脉压、脉压指数可以预测肥胖
的发生。 |
| 英文摘要: |
| Objective: To evaluate the predictive value of pulse pressure (PP) or pulse pressure index (PPI) to obesity in middle-aged
Chinese residents. Methods: A baseline survey for CVD risk factors was carried out in a general population of Chengdu in 1992, and
there are 1017 subjects with normal BMI in 1992. We divided the 1017 middle-aged people into 2 groups according PP/PPI of 1992. The
normal PP group means the PP of the people is less than or equal to 60 mmHg, and the normal PPI group is PPI less or equal to 0.450 in
1992. The augmented PP/PPI group is PP more than 60 mmHg and PPI more than 0.450. We analyzed the distribution of BMI and
prevalence of obesity in 2007 according to PP/PPI of 1992. Results:①The BMI of 2007 in augmented PP/PPI group is higher than that in
normal group. And the difference of BMI is statistically significant. As to prevalence of obesity, the augmented PP/PPI group is also
statistically higher than that in the normal group. ② According to the PP in 1992, the relative risk (RR) is 4.109 (P=0.000), the 95%
Confidence Interval is 2.874～8.847. As to PPI, the RR is 4.998 (P=0.000), the 95% Confidence Interval is 2.876～8.687. ③ Using
logistic regression analysis, the adjusted RR of PP and PPI in 1992 to obesity in 2007 is 1.040 and 1.044 respectively, and the 95%
Confidence Interval is 1.017～1.065 and 1.025～1.063 respectively. Conclusions: The PP and PPI are closely related to the level of BMI
and obesity, and high pulse pressure is associated with increased risk of obesity. PP and PPI might be able to be used for predicting the
incidence of obesity. |
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