| 张拥军1 范久波2△ 李青锋3 胡知朋1 杨俊波1.多西紫杉醇联合适形放疗治疗老年贲门癌患者的疗效观察[J].现代生物医学进展英文版,2012,12(3):525-526. |
| 多西紫杉醇联合适形放疗治疗老年贲门癌患者的疗效观察 |
| Weekly Docetaxel and Concomitant Radiotherapy for the Elderly Patientswith Unresectable Gastric Cancer |
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| DOI： |
| 中文关键词: 进展期贲门癌 周剂量多西紫杉醇 三维适形放疗 |
| 英文关键词: Advanced gastric cancer Weekly docetaxel 3DCRT |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨周剂量多西紫杉醇联合三维适形放疗(3DCRT)治疗进展期贲门癌患者的疗效。方法：2007 年10 月到2009 年5
月38 例不能手术的贲门癌患者行3DCRT，处方剂量62Gy，1.8Gy／次，5 次／周；同时联合多西紫杉醇75mg/m2，每周1 次，连续
6 周。用Kaplan-Meier 法分析患者的中位无进展生存时间。结果：完全缓解12 例，部分缓解18 例，30 名患者缓解(78.9%)，中位无
进展生存时间16.4 个月。治疗过程中的毒副作用轻，患者可以耐受。结论：周剂量多西紫杉醇化疗联合适形放疗对进展期贲门癌
患者是安全、有效的。 |
| 英文摘要: |
| Objective: To explore the efficacy of weekly docetaxel and concurrent 3DCRT in treatment of elderly patients with
unresectable gastric cancer．Methods: During October 2007 to May 2009，38 patients treated with 3DCRT (62 Gy in fractions of 1.8Gy
daily, five times weekly) and concurrent docetaxel (75 mg/m2, one time per week for successive six weeks) .The Kaplan-Meier method
was used to evaluate the median progression-free survival time. Results: Complete response and partial response were observed in 78.9%
of patients. The overall median progression-free survival time was 16.4 months. Toxicities are tolerable. Conclusions: The therapy of
3DCRT plus concomitant chemotherapy based on docetaxel weekly was effective and safe for the treatment of unresectable gastric
cancer. |
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