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肖蓬勃1 李高元1 刘争建1 王洪涛2 苏菲菲2 石苗茜2.福坦治疗高原心脏病的临床观察[J].现代生物医学进展英文版,2012,12(3):511-513.
福坦治疗高原心脏病的临床观察
Clinical Study on Valsartan and Hydrochlorothiazide Tablets(VHT)in the Treatment of HAHD
  
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中文关键词: 福坦  高原心脏病
英文关键词: Valsartan and Hydrochlorothiazide Tablets  Captopril  HAHD
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Author NameAffiliation
XIAO Peng-bo 1, LI Gao-yuan 1, LIU Zheng-jian 1, WANG Hong-tao 2, SU Fei-fei 2, SHI Miao-qian 2 解放军第二十二医院心肺内科 
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中文摘要:
      目的:观察福坦治疗高原心脏病的临床疗效。方法:选择我院2007 年10 月至2010 年10 月收治的高原心脏病伴右心衰患 者86 例,随机分为试验组和对照组,试验组42 例给予福坦治疗,对照组44 例给予卡托普利加氢氯噻嗪治疗,治疗周期为1 年。 比较2 组治疗前后左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、短轴缩短率(FS)、射血分数(LVEF)及6 分钟 步行前后心率、血压、心肌耗氧量并进行统计学分析。结果:试验组LVEF 明显增加,LVEDD、LVESD 明显减小,心率、心肌耗氧量 的降低,较对照组具有统计学差异。结论:福坦具有明显的抗高原心脏病的作用。
英文摘要:
      Objective: To investigate the effects of Valsartan and Hydrochlorothiazide Tablets in the treatment of HAHD . Method: 86 cases of hospitalization in HAHD patients combined with right heart failure would be divided into treatment group(n=42) and control group (n=44).The treatment group was given Valsartan and Hydrochlorothiazide tablets (VHT),and the control group was given Captopril plus Hydrochlorothiazide. Left ventricular end diastolic dimension (LVEDD),left ventricular end-systolic dimension(LVESD) and left ventricular ejection fraction(LVEF) as wel1 as heart rate,systolic pressure,6-minute walking testwere evaluated before and after treatment. Results: After 12 months of treatment ,LVFF and 6-min walking test were improved (P<0.05). The heart rate,systolic pressure,LVEDD and LVESD in the observation group were decreased significantly (P<0.05). There was significant difference between 2 groups(all P<0.05).Conclusion: VHT can obviously improve HADHD.
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