| 张远起陈小东李建文丁洪飞梁启廉黄水传张智.乳腺癌组织中血管内皮生长因子和抑癌基因Maspin
的表达及意义[J].现代生物医学进展英文版,2012,12(3):493-496. |
| 乳腺癌组织中血管内皮生长因子和抑癌基因Maspin
的表达及意义 |
| Expression of Vascular Endothelial Growth Factor and Maspinin Breast Carcinoma and its Clinical Significance |
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| DOI： |
| 中文关键词: 血管内皮生长因子 Maspin 乳腺肿瘤 免疫组织化学 |
| 英文关键词: Endothelial growth factor Maspin Breast neoplasm Immunohistochemical method |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨血管内皮生长因子（vascular endothelial growth factor, VEGF）和抑癌基因Maspin(mammary-serpin)在乳腺癌组织
中的表达。方法：采用免疫组织化学法法检测乳腺癌组织与癌旁正常组织中的VEGF 和Maspin 表达水平。结果：VEGF 在正常乳
腺组织中表达率为44.4%（40/90），在乳腺癌组织中的表达率为91.1%（82/90），Maspin 在正常乳腺组织中表达率为100%（90/90），
在乳腺癌组织中的表达率为68.9%（62/90）。VEGF 蛋白表达水平与乳腺癌TNM 分期、淋巴结转移有关(P<0.01)，Maspin 蛋白的表
达与乳腺癌的组织学分型、分级、淋巴结转移均有关(P<0.05)。结论：检测VEGF 和Maspin 有利于乳腺癌的生物学行为评估和乳
腺癌预后判断。 |
| 英文摘要: |
| Objective: To explore the expression of VEGF and Maspin protein in breast cancer tissues. Methods: We examined the
expression of the level of VEGF and Maspin expression in breast cancer tissues and adjacent breast normal tissues by
immunohistochemistry. Results:The expression rate of VEGF was 91.1%（82/90）in breast carcinoma tissues, but 44.4%（40/90）in normal
tissues; as for Maspin, the case was to contrary, the expression rate of Maspin protein was 68.9%（62/90）in breast carcinoma tissues, and
100%（90/90）in normal tissues. There was correlation between the expression of these two proteins. The expression of VEGF was related
to TNM stage and lymph node metastasis of breast carcinoma (P<0.01), there was a close relation between the expression of Maspin and
histology type, histology grade and lymph node metastasis of breast carcinoma (P<0.05). Conclusion :These results demonstrate that
examination of expression of VEGF and Maspin at the same time might be beneficial in judging biological behavior and prognosis of
breast carcinoma. |
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