| 郭俊1 杨华强2.Mcl-1 分子研究进展[J].现代生物医学进展英文版,2012,12(2):393-397. |
| Mcl-1 分子研究进展 |
| Progression of Rsearch for on Mcl-1 Mlecule |
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| DOI： |
| 中文关键词: 凋亡；Mcl-1；肿瘤 治疗 |
| 英文关键词: Apoptosis Mcl-1 Tumor Treatment |
| 基金项目:湖北省教育厅基金资助（B20092404） |
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| 中文摘要: |
| Mcl-1(myeloid cell leukemia-1)是Bcl-2 家族的一个新成员，在凋亡调控中具有重要作用，此外它还可以直接对细胞分化和细
胞周期进行调控，进一步研究表明Mcl-1 在胚胎形成，组织发育和免疫系统中具有重要作用，Mcl-1 表达异常可以导致恶性肿瘤
的发生，因此通过反义寡核苷酸技术或小分子干扰RNA 抑制Mcl-1 基因的表达, 促进细胞凋亡并提高肿瘤细胞对放疗及化疗的
敏感性, 为难治性肿瘤的治疗开辟了一条新途，所以对Mcl-1 的深入研究具有重要意义。 |
| 英文摘要: |
| Myeloid cell leukemia-1 (Mcl-1), which has important role in regulation of apoptosis besides it directly regulate cell
differentiation and cell cycle, is a new member of B cell lymphoma-2(Bcl-2) families. Further study show that Mcl-1 has important role in
embryogenesis, tissure development, and immune system and abnormal expression ofMcl-1 contribute to tumourgenesis. We may develop
a new approach by inhibiting mcl-1 gene expression through Mcl-1 antisense oligonucleotide or small interfere RNA, facilitate tumour
cell apoptosis, and improve tumor cell sensitivity to radiotherapy and chemotherapy. So it has significant meaning in further study for
Mcl-1. |
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