| 吴春风1 胡柯2 胡小勇1 廖德祥1 曾建平1.不同剂量阿托伐他汀对稳定性心绞痛患者TNF-α 和LDL-C 水平的影响[J].现代生物医学进展英文版,2012,12(2):333-336. |
| 不同剂量阿托伐他汀对稳定性心绞痛患者TNF-α 和LDL-C 水平的影响 |
| Effect of Different Dose Atorvastatin on Stable Angina Pectoris and onthe Levels of TNF-α and LDL-C |
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| DOI： |
| 中文关键词: 阿托伐他汀 稳定性心绞痛 血清肿瘤坏死因子a 低密度脂蛋白胆固醇 |
| 英文关键词: Atorvastatin Stable angina pectoris Tumor necrosis factor-a Low-density lipoprotein cholesterol |
| 基金项目: |
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| 中文摘要: |
| 目的：观察不同剂量阿托伐他汀对冠心病稳定性心绞痛患者血清肿瘤坏死因子a(TNF-α)和低密度脂蛋白胆固醇(LDL-C)水
平的影响。方法：用酶联免疫吸附法和生化发光分析法测定40 例正常对照组和40 例阿托伐他汀10mg 组及39 例阿托伐他汀
20mg 组冠心病患者治疗前后血清TNF-α 和LDL-C 水平的变化。结果：阿托伐他汀10mg 及20mg 组患者治疗12 周后血清
TNF-α 和LDL-C 水平明显降低，并且阿托伐他汀20mg 组比阿托伐他汀10mg 组血清TNF-α 下降更明显,差异有显著性（P <0.
05）,但两组间LDL-C 水平降低无显著性差异（P＞0.05）。结论：阿托伐他汀可以降低冠心病患者血清LDL-C 和TNF-α 水平,减轻
冠心病的炎症反应,并且这种机制独立于降脂作用以外。 |
| 英文摘要: |
| Objective: To investigate the influence of the different dose Atorvastatin on the levels of Tumor necrosis factor-a
(TNF-α) and Low-density lipoprotein cholesterol (LDL-C) in patients with Stable angina pectoris (SAP). Methods: The levels of TNF-α
and LDL-C were measured in 40 normal controls(NC group) and Atorvastatin 10mg group (n=40) and Atorvastatin 20mg group (n=39)
before and after treatment in Stable angina pectoris (SAP). Results: After treatment of 12 weeks, serum level of TNF-α and LDL-C in patients
with Stable angina pectoris was significantly lower, and the level of serum TNF-α in Atorvastatin 20mg group was significantly
lower than those in Atorvastatin 10mg group (P＜0.05), whereas there was no obvious difference about changes of the level of serum
LDL-C between them (P＞0.05). Conclusions: The concentration of TNF-α and LDL-C decreased after treatment of Atorvastatin in SAP,
which indicated that Atorvastatin was available to anti-inflammation in addition to lipid-lowing effects. |
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