| 要英杰邵一兵△ 王旭王正忠.远端保护装置治疗老年急性ST 段抬高型心肌梗死心肌标志物
变化的研究[J].现代生物医学进展英文版,2012,12(2):287-290. |
| 远端保护装置治疗老年急性ST 段抬高型心肌梗死心肌标志物
变化的研究 |
| Study on Cardiac InjuryMarkers Change in the Elderly Patients with STSegment Elevation in Acute Myocardial Infarction Using DistalProtection Device |
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| DOI： |
| 中文关键词: 心肌梗死 远端保护装置 肌钙蛋白I 肌酸激酶，MB 型 |
| 英文关键词: Myocardial infarction Distal protection device Troponin creatine kinase, MB |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨应用远端保护装置GuardWire PlusTM 治疗老年急性ST 段抬高型心肌梗死（STEMI）对外周血肌钙蛋白（cTnI）、
肌酸激酶同工酶（CK-MB）的影响。方法：将2004 年9 月至2009 年12 月在我院行急诊PCI 的60 例年龄>60 岁老年STEMI 患者
分为远端保护组（GW）和非远端保护组（NGW）。于术前、术后4h、8h、12h、16h、24h、2d、3d、5d 分别测定外周血cTnI、CK-MB 水
平，并比较两组间变化及其峰值水平。结果：两组全部病例均成功植入支架。GW组全部成功放置GuardWire PlusTM 远端保护装
置。发病后12h 两组CK-MB 的值有明显差别（P<0.05），并且GW组出现酶峰提前，发病后6h、12h 两组的CTNI 的值有明显差别
（P<0.05）,并且GW组出现峰值提前。结论：老年心肌梗死急诊PCI 中应用远端保护装置可以缩小梗死面积，改善预后。 |
| 英文摘要: |
| Objective: To study the changes in cTnI、CK-MB in the elderly patients with ST segment elevation in acute myocardial
infarction using distal protection device (GuardWire PlusTM). Methods: Sixty STEMI elderly patients who received percutaneous coronary
intervention (PCI) during September 2004 to December 2009 were enrolled in the study. All the patients were divided into 2 groups
which were: the distal protection device group(GW group n=30) and the non- distal protection device group(NGW group n=30)according
to whether distal protection device was applied or not.The cTnI and CK-MB levels were measured on the day of operation and at
4,8,12,16 and 24 hours after the operation, as well as on 2,3,and 5 days after wards. Results: The levels of CK-MB showed a rapid decline
in their plasma levels in the GW group compared with the NGW group on 12h after the operation （P<0.05）. The peak level of
CK-MB of GWgroup showed up earlier compared with the NGWgroup. The levels of cTnI showed a rapid decline in their plasma levels
in the GW group compared with the NGW group on 6h and 12h after the operation （P<0.05）. The peak level of cTnI of GW group
showed up earlier compared with the NGW group. Conclusion: In the elderly patients with ST segment elevation in acute myocardial infarction
using distal protection device can minimize myocardial damage. |
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