| 刘莉霞刘国美孙宇辉何秀萍△.HIF-1α 在卵巢癌中的表达及与化疗耐药相关性研究[J].现代生物医学进展英文版,2012,12(2):276-279. |
| HIF-1α 在卵巢癌中的表达及与化疗耐药相关性研究 |
| Analysis of the Relationship between HIF-1αgene Expression and DrugResistance of Chemotherapy in Ovarian Cancer |
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| DOI： |
| 中文关键词: 卵巢癌 HIF-1α 免疫组织化学 化疗耐药 |
| 英文关键词: Ovarian cancer HIF-1α Drug resistance Immunohistochemical |
| 基金项目:黑龙江省科技攻关资助项目（编号：GB07C32303）；哈尔滨市科技人才研究资助项目（编号：2007RFQXS091）；
教育部春晖计划资助项目（编号：Z2009-1-15006） |
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| 中文摘要: |
| 目的：探讨缺氧诱导因子-1α（HIF-1α）在卵巢癌中的表达及其在卵巢癌化疗耐药中的作用。方法：采用免疫组化方法，检测
96 例卵巢癌组织，45 例良性卵巢肿瘤和30 例正常卵巢组织中HIF-1α 的表达，分析其表达与临床病理特征及化疗耐药的相关
性。结果：卵巢癌中HIF-1α 的表达高于正常卵巢及良性卵巢肿瘤组织，且临床分期越晚其表达越高（P<0.001），而与肿瘤组织类
型、病理分级及患者年龄无显著相关性。HIF-1α 在卵巢癌化疗耐药组阳性率明显高于化疗敏感组（P<0.001）。结论：卵巢癌中
HIF-1α 高表达与卵巢癌的发生、发展、浸润和转移有关，与卵巢癌化疗耐药密切相关，HIF-1α 可成为卵巢癌化疗新的分子治疗靶
点。 |
| 英文摘要: |
| Objective: To investigate the expression of HIF-1α in ovarian cancer and its the relationship with chemotherapy drug
resistance. Methods: The expression of HIF-1α in ovarian tumours was detected and the results in related with drug resistance was studied.
Results: The expression of HIF-1α in ovarian cancer positive rate was higher than that in normal tissues and benign tumours(P<0.001).
The expression of HIF-1α and FIGO stage were relevant (P<0.001).The expression of HIF-1α with histopathological type, pathology
classification and age of patients had no relationship. The expression of HIF-1α in drug resistance group was higher than in sensitive
group (P<0.001). Conclusion: HIF-1α expression may be related with the growth of ovarian cancer, lymph node metastasis and drug resistance.
HIF-1α can become the new molecular therapeutic targets. |
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