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目的：探讨血管内皮生长因子（VEGF）在乳腺浸润性导管癌（IDC））组织中的表达及其与临床病理特征的关系。方法：采用 SP 免疫组化法检测72 例IDC 患者（IDC 组）和30 例乳腺纤维腺瘤（对照组）组织中VEGF 的表达。结果：IDC 组VEGF 阳性表达率为68.1%，显著高于对照组（23.3%），两组相比较有显著性差异（P<0.05）；VEGF 阳性表达与IDC 患者年龄和肿瘤直径大小无相关性，其阳性表达率差异无统计学意义（P>0.05）；而VEGF 水平与临床分期和病理组织学分级、以及肿瘤远处转移之间存在相关性，其阳性表达率有显著性差异（P<0.05）。结论：VEGF 在IDC 组织中呈高表达，VEGF 参与了IDC 发生发展和浸润转移，VEGF 可以作为评价IDC 恶性程度和淋巴结转移的一个新型指标。

英文摘要:

Objective: To study the expression and clinical significance of vascular endothelial growth factor (VEGF) in tissues of patients with invasive ductal carcinoma of breast (IDC). Methods: The VEGF expression from 72 cases of patients with IDC (IDC group) and 30 cases of patients with breast fibroadenoma (control group) tissues were detected by SP immunohistochemical method. Results: The positive rate of VEGF expression of the IDC group was 68.1%, the control group was 23.35%; there was significant difference between the two groups (P <0.05); The positive expression of VEGF was no significant correlation among the different age and tumor diameter, the positive rate of VEGF expression had no significant difference (P>0.05); The positive expression of VEGF was significantly correlated with clinical stage, histological grade and distant metastasis of tumor, the positive rate of VEGF expression had significant difference (P<0.05). Conclusion: The VEGF has high expression in tissues of patients with IDC, the VEGF involves in the 0ccurrence, development, invasion and metastasis of IDC. The VEGF is a new indicator for evaluating the malignant degree and lymph node metastasis of IDC.

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