| 杨华强1,2 张荣环3△ 杜玲1 李东升1 袁雅红1 刘瑜2.脐带间充质干细胞移植对脑瘫患儿运动功能的影响[J].现代生物医学进展英文版,2012,12(2):250-252. |
| 脐带间充质干细胞移植对脑瘫患儿运动功能的影响 |
| Effect of Umbilical Cord Mesenchymal Stem Cell TransplantationTherapy for Cerebral Palsy on Motor Function |
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| DOI： |
| 中文关键词: 脑瘫 治疗 移植 脐带间充质干细胞 |
| 英文关键词: Cerebral palsy Treatment Transplantation Umbilical cord blood mesenchymal stem cells |
| 基金项目:湖北省教育厅基金资助项目（B20092404） |
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| 中文摘要: |
| 目的：探讨脐带间充质干细胞移植治疗对脑瘫患儿运动功能的影响极其应用价值。方法：25 例脑瘫患者给予脐带间充质干
细胞移植治疗，移植方法采用静脉输注联合腰穿鞘内注射的方法。移植术前及移植术后定期采用粗大运动评估量表（Gross Motor
Function Measure, GMFM）及Berg 平衡量表（Berg Balance Scale, BBS）对运动功能的改善情况进行评估并进行综合分析。结果：移
植术后6 月25 例脑瘫患儿中有22 例患者主观上运动功能较前有明显好转，客观上25 例患者GFMF 与BSS 与术前比较有明显
改善（P＜0.05），随访6 月未发现与移植相关的副作用。结论：脐带间充质干细胞移植是一种安全有效的治疗方法，可在一定程度
上改善脑瘫患者的后遗症，提高脑瘫患者的运动功能和生活质量。 |
| 英文摘要: |
| Objective: To observe the effect and application value of umbilical cord mesenchymal stem cells (UC-MSC) transplantation
therapy for cerebral palsy (CP) on motor function. Methods: Twenty-five patients with CP were received UC-MSC transplantation
by intravenous infusion and lumbar puncture intrathecal injections. All patients were followed up for more than six months after transplantation.
The changes of motor function were comprehensive analysis by Gross Motor Function Measure (GMFM) and Berg Balance
Scale(BBS）before treatment and post-treatment regularly. Results: After six months of transplantation, 22 of 25 cases with CP subjectively
had improvement in motor function compared with prior treatment. All patients objectively had improvement in scores of GMFM and
BSS post-treatment than pretherapy. Various biochemical indicators were normal and the patient had no severe complications and clear
side effects after transplantation. All patients' condition was continously catabatic and no recurrence was found after six months was followed
up. Conclusions: The UC-MSC transplantation can ameliorate sequelae and improve motor function and quality of life of CP. It is
convenient, safe and effective in the treatment of CP. |
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