| 曾昭武1,2 周广林2 王小丽3△ 刘星言3 展晓日2.一种榄香烯口服微乳相对生物利用度的初步研究[J].现代生物医学进展英文版,2012,12(2):218-220. |
| 一种榄香烯口服微乳相对生物利用度的初步研究 |
| Study of the Relative Bioavailability of an Elemene Oral Microemulsion |
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| DOI： |
| 中文关键词: 榄香烯 微乳 口服 相对生物利用度 |
| 英文关键词: Elemene Microemulsion Oral Relative bioavailability |
| 基金项目:国家青年自然基金项目（81001647)；浙江省科技厅资助项目（2009C33005）；中国博士后科学基金面上项目（20100471757） |
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| 中文摘要: |
| 目的：研究口服榄香烯微乳在大鼠体内的相对生物利用度。方法：大鼠口服给予榄香烯微乳、榄香烯乳剂后，在不同时间点
采血，采用超快速液相色谱法检测血浆榄香烯的浓度，计算其药动学参数与相对生物利用度。结果：榄香烯微乳粒径为(67±13)
nm；Zeta 电位为(3.2±0.4) mv；pH 值为5.16；粘度为6 mpa·s；表面张力为31.7 mN·m-1。榄香烯微乳中β- 榄香烯含量为(8.273±
0.018) mg·mL-1。榄香烯微乳相对生物利用度为163.1%。结论：大鼠口服榄香烯微乳与榄香烯口服乳相比其生物利用度有较大提
高。 |
| 英文摘要: |
| Objective: To study the relative bioavailability of an elemene oral microemulsion on rats in vivo. Methods: After oral
administration of elemene microemulsion and emulsion, blood was taken out from rats at different time. Plasma concentration of elemene
was detected by ultra-fast liquid chromatography to calculate its pharmacokinetics parameters and relative bioavailability. Results: The
elemene microemulsion was characterized as(67±13) nm in size, (3.2 ±0.4) mv in zeta potential, 5.16 in pH, 6 mpa·s in viscosity, 31.7
mN·m-1 in surface tension,(8.273 ±0.018) mg·mL-1 in content of β-elemene. The relative bioavailability of elemene microemulsion was
163.1%. Conclusion: The relative bioavailability of elemene microemulsion is higher than that of elemene emulsion. |
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