孙宏1 李艺萍1 杨炎2 王秀云3 颜洪海4 苗长青1 梁立波1 宁宁1.2 型糖尿病家系患者PON2 基因9 Ser311C→G 多态性的研究*[J].现代生物医学进展英文版,2012,12(2):210-214. |
2 型糖尿病家系患者PON2 基因9 Ser311C→G 多态性的研究* |
PON2 Gene 9 Ser311C→G Polymorphism in Chinese Families withType 2 Diabetes |
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DOI: |
中文关键词: 2 型糖尿病 PON2 基因 单核苷酸多态性 |
英文关键词: Type 2 diabetes PON2 gene Single nucleotide polymorphism |
基金项目:国家自然科学基金(30671802);黑龙江省教育厅科学技术研究项目(11521145);黑龙江省卫生厅医学科研项目(2006-291); |
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中文摘要: |
目的:研究黑龙江地区汉族人2 型糖尿病家系的PON2 基因9 Ser311C→G 多态性,探讨其与2 型糖尿病发病的关系。方法:
应用聚合酶链式反应- 限制性内切酶长度多态性(PCR-RFLP)技术,对来自于黑龙江地区120 个2 型糖尿病家系中的210 例2 型
糖尿病患者及319 例正常对照的PON2 基因9 Ser311→Cys(C→G)位点进行基因分型。结果:PON2 基因9 Ser311C→G 三种基因
型在病例组和对照组间整体分布没有统计学意义(P=0.610,df=2);各基因型及等位基因在病例组和对照组间分布没有统计学意义
(P>0.05)。结论:PON2 基因9 Ser311C→G 多态性与黑龙江地区汉族人2 型糖尿病无关,PON2 基因可能不是中国人2 型糖尿病
发病的相关易感基因。 |
英文摘要: |
Objective: To detect PON2 gene 9 Ser311C→G polymorphism in Heilongjiang Han families with type 2 diabetes and
to investigate their relationship with type 2 diabetes. Methods: PCR-RFLP method was used to detect the site of PON2 gene 9 Ser311→
Cys(C→G) in 210 individuals from 120 type 2 diabetes families and 319 normal control subjects in Heilongjiang area. Results: The overall
distribution of the three genotypes of PON2 gene 9 Ser311C→G between cases and controls had no significant difference (P=0.610,
df=2). The distribution of the all of the genotypes and alleles between cases and controls had no significant difference (P>0.05). Conclusion:
PON2 gene 9 Ser311C→G polymorphism is not related to type 2 diabetes in Heilongjiang Han nationality. PON2 gene may not be a
related gene of type 2 diabetes in Chinese. |
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