| 郑义1 高丽敏2 井明霞3 张金丽3 芮东升3 王英红2 阿曼古丽2
何玲3 赵娟3 杨磊3△.新疆维族妇女感染的HPV 型别分布的研究[J].现代生物医学进展英文版,2012,12(1):108-111. |
| 新疆维族妇女感染的HPV 型别分布的研究 |
| Distribution and Prevalence of Human Papillomavirus (HPV) Genotypesin 2473 Cytological Samples Of Xinjiang Uyghur Women |
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| DOI： |
| 中文关键词: 新疆 人乳头瘤状病毒（HPV） 基因分型 子宫颈癌 |
| 英文关键词: Xinjiang Human papillomavirus (HPV) Genotyping Cervical cancer |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨人乳头瘤状病毒（Human papillomavirus，HPV）在新疆南部维族妇女人群中的型别分布情况。方法：以年龄在
30-59 岁的新疆伽师县夏普吐勒乡维吾尔族妇女人群为基础进行筛查，签署知情同意书后，采集受试者宫颈脱落细胞，利用PCR
和基因芯片技术检测HPV DNA 并分型。结果：共2473 名妇女入选。HPV 总的感染率为9.1%，高危型中HPV-16 的感染率最高为
6.9%，其他高危型的感染率从高到低依次为：HPV-59、HPV-56、HPV-18、HPV-33、HPV-58、HPV-51、HPV-31、HPV-45、HPV-52、
HPV-68、HPV-35、HPV-39。低危型中HPV11 感染率最高，其他低危型的感染率从高到低依次为HPV-42、HPV-43、HPV-6、
HPV-53、HPV-66、HPV-73。HPV-44、-83、-MM4 没检测到。多重感染率为34.2%。结论：新疆维吾尔族妇女人群中以HPV16 感染
为主，其次为HPV59、56、18、33 等。HPV59 可能是新疆维吾尔族妇女较易感染的类型。体现了新疆维吾尔族妇女感染HPV 的特
殊性。 |
| 英文摘要: |
| Objective: To investigate the types distribution of human papillomavirus (HPV) in women in Xinjiang Uyghur women.
Methods: Women between 30 and 59 were chosen in cluster stratified sampling from XiaPuTaoLe Town, Xinjiang and received a population-
based cervical cancer screening. After consent, everywoman was detected and genotyped HPV DNA by PCR and Gene Chip. Results:
2473 women were chosen. The total infection rate of HPV was 9.1% . The positive rate of HPV-16 infection was 6.9% among the
High-Risk HPV indicating it was the most common infection. Other High-Risk HPV infection rates were ranked from high to low:
HPV-59,HPV-56,HPV-18,HPV-33, HPV-58,HPV-51,HPV-31,HPV-45,HPV-52,HPV-35,HPV-39,HPV-68. HPV-11 was the most common
infection among the Low-Risk HPV types. Other Low-Risk HPV infection rates were ranked from high to low: HPV-42, HPV-43,
HPV-6, HPV-53, HPV-66, HPV-73. HPV-44, -83, -MM4 were not detected. The multiple infection rate was 34.2%. Conclusion: HPV-16
was the most common types in the study population. The next most common types of HPV were HPV59, 56, 18,33. Xinjiang Uighur
women had the relatively higher risk of suffering HPV59 infection indicating the specificity of HPV infection in Xinjiang Uighur women. |
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