王芳刘莉洪喆吴琦於健.两种的晚期胃癌化疗方案的疗效及成本对比研究[J].现代生物医学进展英文版,2012,12(1):77-79. |
两种的晚期胃癌化疗方案的疗效及成本对比研究 |
Cost Ettectiveness Analysis of two Chemotherapy Schemas on AdvancedGastric Carcinoma |
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DOI: |
中文关键词: 胃癌 CS 方案;S-1;成本效果分析 |
英文关键词: Gastric carcinoma CS chemotherapy schema S-1 Cost ettectiveness analysis |
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中文摘要: |
目的:运用药物疗效及经济学方法研究CS 辅助化疗与ECF 化疗方案,进行成本效果对比分析,为临床合理选用胃癌化疗
方案提供参考。方法:选择67 例中晚期胃癌患者,随机分为A 组(CS,32 例)组和B 组(ECF 组,35 例),A 组给予CS 方案辅助化
疗,B 组给予ECF 方案化疗,3 个周期为l 疗程,均治疗3 个疗程后评价治疗效果及副作用,进行成本效果分析。结果:A 组与B 组
治疗效果比较差异无显著性差异(P>0.05),A 组治疗的有较低的相关死亡率,但与B 组比较差异无统计学意义(3.13% vs8.57%,
P>0.05),A 组Ⅲ/Ⅳ度中性粒细胞降低(12.56% vs 37.14%)、Ⅲ/Ⅳ度粒细胞减少性发热(3.13% vs 20.0%)、Ⅲ/Ⅳ度口腔粘膜炎
(3.13% vs 22.90%)、肾毒性(15.6% vs 37.10%)、严重低钾血症(6.30% vs 40.0%)的发生率均低于B 组(P<0.05)。A 组成本较高,
并且由于成本增加,有较高的成本效益比。结论:CS 方案虽然有较好安全性,但因成本增加,有较高的成本效益比,患者应根据经
济能力选择合适的治疗方案。 |
英文摘要: |
Objective: To analyze the cost and ettectiveness of two chemotherapy schemas on advanced gastric carcinoma. Methods:
67 cases with advanced gastric carcinoma are randomized into two groups: group A(CS group,32 cases) and group B(ECF group,35 cases),
while the group A take CS chemotherapy schema for 3 courses of treatment. The group B take ECF chemotherapy schema for 3
courses of treatment. Analyze the treatment effectiveness, side effect and cost ettectiveness. Results: The treatment effec- tiveness of two
chemotherapy schemas has no difference(P>0.05). Group A has lower correlated death rate than group B, but the difference has no statistically
significance (P>0.05). The cases in group A have lower rate than group B in Ⅲ/Ⅳ grate neutrophilic granulocyte decline
(12.56% vs 37.14%), febrile(3.13% vs 20.0%),Ⅲ/Ⅳgrate oral mucositis(3.13% vs 22.90%), renal toxicity(15.6% vs 37.10%), severe
hypokalemia (6.30% vs 40.0%)(P<0.05); Group A has higher cost and cost ettectiveness than group B. Conclusion: CS chemotherapy
schema has better safe reliability, higher cost and cost ettectiveness than group B. The patient should choose suitable chemotherapy
schemas depending on economic ability. |
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