| 刘国美刘莉霞郭西雨陈莹孙宇辉何秀萍△.卵巢癌中Caspase-3 的表达及与化疗耐药相关性研究[J].现代生物医学进展英文版,2012,12(1):73-76. |
| 卵巢癌中Caspase-3 的表达及与化疗耐药相关性研究 |
| Relationship between the Expression of Caspase-3 and Chemoresistancein Epithelial Ovarian Cancer |
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| DOI： |
| 中文关键词: 卵巢癌 Caspase-3 组织芯片 免疫组织化学 化疗耐药 |
| 英文关键词: Ovarian Carcinoma Caspase-3 Tissue Microarray Drug Resistance |
| 基金项目:黑龙江省科技攻关资助项目（GB07C32303）；哈尔滨市科技人才研究资助项目（2007RFQXS091）； |
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| 中文摘要: |
| 目的：检测Caspase-3 在卵巢癌中的表达并探讨其与卵巢癌化疗耐药相关性。方法：利用组织芯片技术结合免疫组化方法，
对176 例卵巢癌、70 例良性卵巢肿瘤、50 例正常卵巢组织中Caspase-3 的表达进行检测，分析其表达与临床病理特征及化疗疗效
的相关性。结果：卵巢癌中Caspase-3 的表达显著低于正常卵巢及卵巢良性肿瘤，且卵巢癌FIGO 临床分期越晚其表达越低（P<0.
01），而与肿瘤的组织类型、病理分级及患者的年龄和月经状况无显著相关性(P>0.05)。Caspase-3 在卵巢癌化疗耐药组的阳性率显
著低于化疗敏感组（P<0.01）。结论：凋亡蛋白酶Caspase-3 的缺表达可能参与了卵巢癌的发生发展过程，在卵巢癌化疗耐药的行程
中发挥作用；Caspase-3 的检测可能对指导卵巢癌临床化疗用药有帮助，可提高化疗效果和减少化疗耐药，并成为预测化疗疗效的
有用指标。 |
| 英文摘要: |
| Objective: To investigate the expression of Caspase-3 in epithelial ovarian cancer and analyze its relationship with the
drug resistance of chemotherapy. Methods: Tissue microarray (TMA) technolocy and immunohistochemical techniquewere used to detect
the expression of Caspase-3 in ovarian tumor tissues. The relationship among Caspase-3, clinicopathological features and drug resistance
was analysised. Results: The expression of Caspase-3 was significantly correlated with the clinical stage of ovarian carcinoma(P<0.01).
Expression rate of Caspase-3 in drug resistance group was lower than that in sensitive group (P<0.01). Conclusion: Caspase-3 may play a
significant role in the process of carcinogenesis of ovarian cancer; Loss of Caspase-3 expression is correlated with prognosis and drug resistance.
Detection of Caspase-3 may guide the using of chemotherapy drugs of ovarian cancer and improve of chemotherapeutics effect
and decrease drug resistance, and then improve the prognosis of ovarian carcinoma patients. |
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