| 王健生1 李长锋2△ 金景鹏2 徐惠明1 陈小芳1 薛俊明1.以左氧氟沙星为基础的三联疗法根除幽门螺杆菌的疗效分析[J].现代生物医学进展英文版,2011,11(21):4168-4170. |
| 以左氧氟沙星为基础的三联疗法根除幽门螺杆菌的疗效分析 |
| Efficacy of levofloxacin-based triple therapy to eradicate helicobacterpylori infection |
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| DOI： |
| 中文关键词: 左氧氟沙星 幽门螺杆菌 三联疗法 根除率 |
| 英文关键词: Levofloxacin Helicobacter pylori Tripletherapy Eradication |
| 基金项目: |
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| 中文摘要: |
| 目的：本研究的目的是评估以左氧氟沙星为基础的三联疗法根除幽门螺杆菌的疗效分析。方法：112例通过快速尿素酶试验
和13C- 尿素呼气试验证实感染了幽门螺杆菌的非溃疡性消化不良的患者入组本实验，患者被随机分为7d 组（54 例)和14d 组
（58 例），接受包括雷贝拉唑(10 mg b.i.d.)加左氧氟沙星(500 mg q.d.)和阿莫西林(1000 mg b.i.d.)的治疗，并进行6 周的随访，治疗
结束至少4周后通过13C-尿素呼气试验确定根除率。结果：幽门螺杆菌总的根除率为83.9%（ITT）和88.7%（PP）。7d组51 名患
者完成了治疗，其根除率为75.9%（ITT）、80.4%（PP），而14d组的根除率达到91.4%（ITT）、96.4%（PP），P<0.05。结论：包含雷贝拉
唑、左氧氟沙星和阿莫西林的三联疗法对于根除幽门螺杆菌是有效的，但相同方案的14d疗法疗效明显优于7d疗法。 |
| 英文摘要: |
| Objective: To evaluate the efficacy of levofloxacin-based triple therapy to eradicate helicobacter pylori infection.
Methods: One hundred and twelve non-ulcer dyspeptic patients infected with Helicobacter pylori as diagnosed by both a rapid urease test
and 13C-urea breath test were included in this study. Patients were randomized to receive either 7- d Group （54 patients）or 14-d Group
（58 patients）therapy with rabeprazole (10 mg b.i.d.), plus levofloxacin (500 mg q.d and amoxicillin (1000 mg b.i.d.) and they were followed
for six weeks. Eradication was assessed by 13C-urea breath test four weeks after completing the treatment protocols. Results: The
H. pylori eradication was 83.9% and 88.7% by intention to treat (IIT) and per protocol analysis (PP)analyses, respectively. In 7-d Group,
51 patients completed the treatment and the eradication rate was 75.9%（ITT）, 80.4%（PP）. In 14-d group, 55 patients completed the
treatment and the eradication rate was 91.4%（ITT）, 96.4%（PP），(P<0.05 vs 7-d group ). Conclusions: Triple therapy with rabeprazole,
levofloxacin and amoxicillin was effective for Helicobacter pylori eradication, but 14-day therapy with the same protocol was more effective. |
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