| 王书昌1 杨学伟2 张玉玲2△ 张昊1.乳腺癌中Survivin和VEGF的表达[J].现代生物医学进展英文版,2011,11(21):4159-4162. |
| 乳腺癌中Survivin和VEGF的表达 |
| Survivin and VEGF Expressions in Breast Cancer and their Relations |
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| DOI： |
| 中文关键词: 乳腺癌 Survivin VEGF 免疫组化 |
| 英文关键词: Breast carcinoma Survivin VEGF Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：研究抗凋亡蛋白Survivin,血管内皮生长因子VEGF在乳腺癌中的表达情况，探讨二者的表达与乳腺癌侵袭的关系以
及二者之间的联系。从而为临床诊断和治疗乳腺癌提供参考价值。方法：应用免疫组织化学方法检测Survivin和VEGF在41例
乳腺癌标本中和10 例正常乳腺组织对照组中的表达情况。结果：与对照组相比，乳腺癌中Survivin 的阳性表达（68.29％）与
VEGF的表达（63.41％）明显升高，且他们的表达与肿瘤的淋巴结转移和c-erBb-2 有相关性。而与患者的年龄、临床分期、ER、PR
和肿瘤大小无明显相关性。Survivin表达与VEGF表达呈明显正相关（P＜0.01）。结论：Survivin(生存素)与VEGF(血管内皮生长
因子)的表达在乳腺癌的发生、发展中起重要作用。Survivin的高表达促进了VEGF的促内皮细胞功能。 |
| 英文摘要: |
| Objective: To study the expression of Survivin and VEGF in breast carcinoma tissue, and their relation to the
invasiveness and metastasis in breast cancer. Methods: Immunohistochemistry was used to detect the expression of Survivin and VEGF in
41 breast cancer and 10 normal breast tissue. Results: The positive expressions of Survivin and VEGF in breast cancer was 68.29％ and
63.41％ respectively, both higher than that in normal breast tissue (p＜0.05). And the expression of Survivin and VEGF was positive
related to the lymph node metastasis and c-erBb-2, but with no significant correlation with age, clinical stage, ER, PR and tumor size. The
expression of Survivin was positively related to the expression of VEGF. Conclusion: The expression of Survivin and VEGF may play an
important role in the occurrence and development of breast carcinomas. The high expression of Survivn promoted the function of VEGF
which boost the growth of the endothelial cell. |
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