李学东1 赵恩阳1 王长林1 徐万海2.THP在早期非肌层侵润性膀胱癌定位诊断与治疗中的临床应用[J].现代生物医学进展英文版,2011,11(21):4106-4108. |
THP在早期非肌层侵润性膀胱癌定位诊断与治疗中的临床应用 |
Clinical Application of Localization Diagnosis and Treatment in the EarlyNon-Muscle Invasive Bladder Cancer with THP* |
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DOI: |
中文关键词: THP 非肌层侵润性膀胱癌 定位诊断 治疗 |
英文关键词: THP Non-muscle invasive bladder cancer Localization diagnosis Treatment |
基金项目:哈尔滨市科技攻关计划项目资助(编号:2007AA3CS083-5) |
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中文摘要: |
目的:探讨THP在早期非肌层侵润性膀胱癌定位诊断与治疗中的临床应用价值。方法:已诊断非肌层侵润性膀胱癌患者45
例,术中均实行THP膀胱灌注,灌注后15min 置入膀胱镜,观察膀胱内粘膜,将THP橙色染色区域作为实验组进行活检,其他未
染色区域作为对照组随机活检,活检组织行病理检查。TUR-BT术后将45例患者随机分为3 组,在不同的时间点开始灌注(术后
即刻、术后6小时、术后7 天),比较复发率和平均复发时间。结果:两组间比较具有统计学意义(P<0.05)恶性粘膜吸收THP敏感
度和特异度分别为100%、63.5%;TUR-BT 术后即刻灌注及6 小时后灌注的总复发率明显低于术后7 天灌注,差异有统计学意义
(P<0.05)。结论:THP对非肌层侵润性膀胱癌早期定位诊断准确、安全性好,同时术后早期灌注THP可以降低肿瘤的复发率,值得
临床推广。 |
英文摘要: |
Objective: To discuss the value of clinical application in the early non-muscle invasive bladder cancer with THP.
Methods: 45 patients which had been diagnosised non-muscle invasive bladder cancer were selected as research subjects. The patients received
intravesical treatment with THP in operation and observated the bladder mucosa 15 minutes after intravesical treatment with cystoscopy.
THP orange stained area was biopsied as the experimental group for pathological examination and other unstained area as the
control group. 45 patients after TUR-BT were divided into 3 groups with randomized. The patients received intravesical treatment at different
times (immediately after TUR-BT, 6 hours after TUR-BT, 7 days after TUR-BT). Then the recurrence rate and average recurrence
time were compared. Results: The comparison of results between the two groups had statistical significance (P<0.05). The sensitivity and
specificity for THP absorbtion by malignant mucosa were 100% and 63.5%, respectively. Overall recurrence rate of immediately after
TUR-BT and 1 day after TUR-BT obviously lower than 1 week after TUR-BT.There were statistical significance (P<0.05). Conclusion:
THP is exactly and good security in early localization diagnosis of non-muscle invasive bladder cancer. And the early postoperative infusion
can reduce the rate of tumor recurrence rate. It is worthy of popularization and application. |
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