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目的：探讨睾丸间质细胞瘤的临床病理特点及诊疗方法。方法：分析并总结3 例睾丸间质细胞瘤患者的临床病理资料并文献复习。结果：1例术中冰冻切片诊断为睾丸间质细胞瘤，2例术前细针穿刺病理诊断为睾丸间质细胞瘤，病理组织学表现为瘤细胞呈团、条索或弥漫分布，体积较大，呈多角形胞质丰富嗜酸性，边界清楚。2 例患者行单侧睾丸切除，1 例行睾丸肿瘤剜除术，术后分别随访24、15、10个月未见复发。结论：睾丸间质细胞瘤发病率低，临床表现缺乏特异性，易误诊，确诊需依赖病理组织学检查，细针穿刺病理可明确诊断并有助于手术的选择及手术范围的确定。

英文摘要:

Objective: To investigate the chinicopathological characteristics, diagnosis and treatment of adult Leydig cell tumor of the testis. Methods: Summarize the clinical and pathological data from 3 cases of the testis Leydig cell tumor, retrospectively analyze and review literatures from September 2008 to February 2010. Results: Leydig cell tumor of the testis was diagnosed by 覱ne-needle aspiration cytology (FNAC) and intraoperative frozen section. Microscopically, the neoplasm was composed of medium-large sized cells of abundant eosinophilic cytoplasm arranged in cords, nets or diffusion. The tumor cells were usually predominantly polygonal with clear margin. Two Patients were treated with ipsilateral orehiectomy, and another one was treated with testis-sparing surgery (TSS) . All patients underwent postoperative follow-up, respectively 24, 15, 10 months. No local recurrence or distant metastasis was observed during the follow- up. Conclusion: The testicular Leydig cell tumor is a rare carcinoma lacking of atypical clinical manifestation and easily misdiagnosed in clinic. The diagnosis can be made by pathological examination. Fine-needle aspiration can confirm the diagnosis and contribute to the extent of surgery options.

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