| 李铁1 杨柳2.肥胖患者载脂蛋白M水平及其与炎症因子的关系研究[J].现代生物医学进展英文版,2011,11(21):4072-4074. |
| 肥胖患者载脂蛋白M水平及其与炎症因子的关系研究 |
| Apolipoprotein M Levels and its Relationship with Inflammatory Factorsin Obesity |
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| DOI： |
| 中文关键词: 肥胖 载脂蛋白M 炎症因子 |
| 英文关键词: Obesity Apolipoprotein M Inflammatory factors |
| 基金项目: |
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| 中文摘要: |
| 目的：观察肥胖患者载脂蛋白M水平并探讨其与炎症因子的关系。方法：58例体重正常者和36例肥胖患者常规测量体重、
身高，计算体重指数，抽取空腹静脉血检测血脂、血浆载脂蛋白M（apoM）、白细胞介素-6（IL-6）、C 反应蛋白（CRP）、肿瘤坏死因
子α（TNF-α）。结果：肥胖患者血浆apoM、高密度脂蛋白胆固醇（HDL-C）降低（P<0.05)，IL-6、TNF-α、CRP水平升高（P<0.05)，肥
胖患者血浆apoM与HDL-C正相关，血浆apoM与IL-6、TNF-α、CRP水平负相关。结论：肥胖患者血浆apoM显著降低，apoM水
平与CRP、TNF-α、IL-6水平密切相关，apoM可能受到这些炎症因子的调控。 |
| 英文摘要: |
| Objective: To observe the level of apoM in obesity and explore the relationship between apoM and inflammatory factor.
Methods: Obese patients (n=36) and healthy volunteers (n=58)were included, and their weight and height were measured. The Plasma
apoM, fasting plasma lipids, Interleukin -6 (IL-6), C-reactive protein (CRP), tumor necrosis factor-α (TNF-α) were measured. Results:
Obesity had lower plasma apoM, lower HDL-C (P<0.05). Conversely, IL-6, TNF-α, CRP increased markedly in obesity group (P<0.05).
In obesity, apoM was positively related to HDL-C level and negatively related to IL-6, TNF-α and CRP. Conclusions: Obese patients
had lower apoM plasma. ApoM levels was closely related to CRP, TNF-α and IL-6 levels in obese patients. apoM may be regulated by
these inflammatory factors. |
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