范强阿地力江·伊明△ 王水泉甘子明.小茴香对肝纤维化大鼠脂质过氧化水平的影响[J].现代生物医学进展英文版,2011,11(21):4043-4046. |
小茴香对肝纤维化大鼠脂质过氧化水平的影响 |
Effects of foeniculum vulgare mill on lipid peroxidation in rats withliver hepatic fibrosis |
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DOI: |
中文关键词: 小茴香 肝纤维化 脂质过氧化 |
英文关键词: Foeniculum Vulgare Mill Hepatic Fibrosis Lipid Peroxidation |
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中文摘要: |
目的:研究小茴香对肝纤维化大鼠的脂质过氧化水平的影响。方法:取Wister大鼠100只,随机取12 只设为正常组,其余采
用四氯化碳(CCL4)复合因素法复制肝纤维化大鼠模型,复制成功后随机分为模型对照组、小茴香组和复方丹参组(n=12);相应药
物干预8 周后,镜检肝组织形态学改变;全自动生化分析仪检测外周血清丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)水平与血
清总蛋白(TP)、白蛋白(ALB)含量;生化法检测肝组织羟脯氨酸(HYP)与血清丙二醛(MDA)含量及超氧化物歧化酶(SOD)、谷胱
甘肽过氧化物酶(GSH-PX)、过氧化氢酶(CAT)活性。结果:HE 结果显示:模型组肝脏炎症与脂肪变性明显,经小茴香干预后明
显改善。生化检测结果显示:与正常组比较,模型组ALT、AST 水平显著升高(P<0.05),TP、ALB 含量显著降低(P<0.05),HYP、
MDA 含量显著增加(P<0.05),而SOD、GSH-PX 和CAT 活性显著降低(P<0.05);与模型组比较,小茴香组ALT、AST 水平显著
下降(P<0.05),TP、ALB 水平显著升高(P<0.05);HYP、MDA 含量显著降低(P<0.05),SOD、GSH-PX 和CAT 活性显著提高
(P<0.05)。结论:小茴香的抗肝纤维化作用可能与调节大鼠脂质过氧化水平有关。 |
英文摘要: |
Objective: To observe the effects of foeniculum vulgare mill on liver fibrosis. Methods: 100 Wister rats were randomly
divided into 4 groups as control group,model group, foeniculum vulgare mill group, and danshen group. Liver fibrosis models were established
by the combination of injecting carbon tetrachloride (CCL4) subcutaneously. Drugs were lavaged for 8 weeks, rats livers tissue
were examined with HE staining; the serum level of alanine transaminase (ALT), aspartate aminotransferase(AST), albumin(ALB) and
total protern (TP) were determined using corresponding test kits; the hepatic lipid peroxidation indexes, including malondialdehyde
(MDA), Superoxide dismutase(SOD),Glutathione peroxidase(GSH-PX),Catalase(CAT) were measured by biochemical methods; Results:
Compared with normal group, ALT, AST level and MDA content remarkablely increased, level of TP, ALB and SOD activity decreased
(P<0.05). Compared with model group, Foeniculum Vulgare Mill group ALT, AST level and MDA content remarkablely decreased, level
of TP, ALB and SOD, GSH-PX, CAT activity remarkablely increased (P<0.05). Conclusions: Foeniculum Vulgare Mill can inhibit the
hepatic fibrosis and it's probably mechanism is associated with the effect of Foeniculum Vulgare Mill regulate the lipid peroxidation in
the liver. |
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