| 钟晨黄瑾△.泛素连接酶对Notch 信号途径的调节作用[J].现代生物医学进展英文版,2011,11(20):3981-3983. |
| 泛素连接酶对Notch 信号途径的调节作用 |
| Regulated Effects of Ubiquitin Ligase on Notch Signaling Pathway |
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| DOI： |
| 中文关键词: Notch 信号途径 Su(dx)/Itch Sel-10 Neuralized LNX |
| 英文关键词: Notch signaling pathway Su(dx)/Itch Sel-10 Neuralized LNX |
| 基金项目:国家自然科学基金（30760063） |
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| 中文摘要: |
| Notch 信号途径是生物进化过程中高保守的信号通路，对细胞的定向发育及成熟起到决定性的作用。Notch 信号途径受到多
种分子机制的严格调控。近年来，多项研究均突出了泛素化在调控Notch 信号途径活性中的重要性。本文就四种E3 泛素连接酶
Su(dx)/Itch、Sel-10、LNX 以及Neuralized 对于调控Notch 受体及Notch 信号途径配体的研究现况作一综述。 |
| 英文摘要: |
| Notch signaling pathway is a conserved signaling pathway in the organic evolution process, and plays a decisive role
in the orientation of cell growth and maturation. Notch signaling pathway is regulated strictly by a varirty of molecular mechanisms. In
recent years, many studies have highlighted the importance of ubiquitination in the regulate of Notch signaling pathway. This paper
summarized four types of E3 ubiquitin ligase Su(dx) / Itch, Sel-10, LNX, and Neuralized regarding regulate the Notch acceptor and Notch
signal way ligand. |
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