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目的：探讨凝血因子Ⅶ基因5'F7 多态性与中国汉族人冠心病的关系。方法：利用聚合酶链反应- 限制性片段长度多态性方法测定43 例健康人（正常对照组）和116 例冠心病患者5'F7 多态性，确定其基因型；统计分析其与冠心病的关系及与冠状动脉狭窄程度的相关性。结果：CHD 组与对照组之间5'F7 多态性的基因型P0P0 与（P0P10+P10P10）频率分布差异总体比较有统计学意义（X2=2.416，P<0.05）,P0、P10 等位基因在两组间的频率分布总体差异有统计学意义（X2=2.302，P<0.05）。结论：FⅦ基因5'F7 多态性中P10 等位基因可能是CHD 的遗传保护因子，但与其病变支数无关。

英文摘要:

Objective: To investigate the relationship between polymorphism of Coagulation Factor Ⅶ and coronary artery disease. Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was adopted to study the 5'F7 polymorphism of Coagulation Factor Ⅶ of controls (43) and patients (116); the correlation between the CHD and 5'F7 polymorphism. Results:There was a significant difference in the frequency distribution of P0P0 and （P0P10+P10P10）of 5'F7 polymorphism between the cases of control group and CHD patients （X2=2.416，P<0.05）;There was a statistical significance in the frequencies distributional difference in the allelomorphic gene P0 and P10 between the two groups（X2=2.302，P<0.05）. Conclusion: The allelomorphic gene P10 of 5'F7 polymorphism is possible geno-protective factor of CHD,but it is not related with number of pathological changed coronary artery.

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