魏涛1 孙雪荣2 陈艳萍2.凝血因子Ⅶ5'F7 基因多态性与冠心病的相关性研究[J].现代生物医学进展英文版,2011,11(20):3916-3918. |
凝血因子Ⅶ5'F7 基因多态性与冠心病的相关性研究 |
Relationship between 5'F7gene Polymorphism of Coagulation Factor Ⅶ andCoronary Heart Disease |
|
DOI: |
中文关键词: 冠状动脉 凝血因子Ⅶ 基因多态性 |
英文关键词: Coronary Coagulation Factor Ⅶ Gene polymorphism |
基金项目: |
|
Hits: 691 |
Download times: 837 |
中文摘要: |
目的:探讨凝血因子Ⅶ基因5'F7 多态性与中国汉族人冠心病的关系。方法:利用聚合酶链反应- 限制性片段长度多态性方
法测定43 例健康人(正常对照组)和116 例冠心病患者5'F7 多态性,确定其基因型;统计分析其与冠心病的关系及与冠状动脉狭
窄程度的相关性。结果:CHD 组与对照组之间5'F7 多态性的基因型P0P0 与(P0P10+P10P10)频率分布差异总体比较有统计学意
义(X2=2.416,P<0.05),P0、P10 等位基因在两组间的频率分布总体差异有统计学意义(X2=2.302,P<0.05)。结论:FⅦ基因5'F7 多态
性中P10 等位基因可能是CHD 的遗传保护因子,但与其病变支数无关。 |
英文摘要: |
Objective: To investigate the relationship between polymorphism of Coagulation Factor Ⅶ and coronary artery
disease. Methods: Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) was adopted to study the 5'F7
polymorphism of Coagulation Factor Ⅶ of controls (43) and patients (116); the correlation between the CHD and 5'F7 polymorphism.
Results:There was a significant difference in the frequency distribution of P0P0 and (P0P10+P10P10)of 5'F7 polymorphism between the
cases of control group and CHD patients (X2=2.416,P<0.05);There was a statistical significance in the frequencies distributional
difference in the allelomorphic gene P0 and P10 between the two groups(X2=2.302,P<0.05). Conclusion: The allelomorphic gene P10 of
5'F7 polymorphism is possible geno-protective factor of CHD,but it is not related with number of pathological changed coronary artery. |
View Full Text
View/Add Comment Download reader |
Close |