| 张玉晶赵霞霞田执梁姜伟杨艳辉.外源性磷酸肌酸对重度窒息新生儿血清S-100B 蛋白
及NSE 水平的影响[J].现代生物医学进展英文版,2011,11(20):3894-3896. |
| 外源性磷酸肌酸对重度窒息新生儿血清S-100B 蛋白
及NSE 水平的影响 |
| Effects of Exogenous Phosphocreatine on Level of S-100B Protein and NSEin Serum of Newborn with Serious Asphyxia |
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| DOI： |
| 中文关键词: 磷酸肌酸 缺氧缺血 S-100 NSE NBNA 评分 |
| 英文关键词: exogenous phosphocreatine hypoxia -ischemic Encephalopathy NSE S100b protein NBNA score |
| 基金项目:黑龙江省卫生厅课题（2007-324） |
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| 中文摘要: |
| 目的：探讨外源性磷酸肌酸对重度窒息新生儿血清S-100B 蛋白和特异性神经元烯醇化酶含量（NSE）的影响。方法：重度窒
息的新生儿40 例，随机分为两组，常规治疗组21 例，给予一般治疗（氧疗、支持、对症）和胞二磷胆碱治疗。磷酸肌酸治疗组19 例，
在常规治疗基础上，生后12h 内给予磷酸肌酸治疗1g/d），另外同期住院的新生儿湿肺和黄疸患儿14 例为正常对照组。均与生后
48h 和生后10 天取血检测血清S-100B 蛋白和NSE 含量。并于生后第14 天进行新生儿行为神经测定（NBNA 评分）。结果：磷酸
肌酸治疗组和常规治疗组患儿生后48h 血清S-100B 蛋白和NSE 含量无显著差异（※P＞0.05，※P＞0.05），与正常对照组比较差
异具有显著性（△P<0.05，△P<0.05），生后10 天血清S-100B 和NSE 含量在常规治疗组患儿和磷酸肌酸组相比具有显著差异，磷
酸肌酸治疗组两者明显下降（※P＜0.05，※P＜0.05）。生后三周的行为神经评估(NBNA 评分)<35 分者所占百分比磷酸肌酸治疗
组27％与常规治疗组组53％比较，差异均具有显著性意义(x2＝6.112，※P<0.05)。结论：磷酸肌酸用于治疗新生儿缺氧缺血性脑
病能够改善脑的能量代谢，降低脑损伤的程度，改善神经行为，降低致残率。 |
| 英文摘要: |
| Objective: To observe the effect of exogenous phosphocreatine on the level changes of S100b protein and NSE In
serum with serious hypoxia -ischemic encephalopathy in newborn infants. Methods: 40 serious asphxia newborn were randomly devided
into two groups: routin therapy group(21 newborns), routin treatment with oxygen ,nutrition and citicoline(CTL).The treatment group(19
newborns) were given exogenous phosphocreatine(12h after born, 1g/d) besides conventional therapy which was given in control only.the
control group (14 newborn)without asphyxia newborns.The content of S100b protein and NSE in serum were measured using
enzyme-linked immuradsorbent assay (ELISA) after 48h and 10 days.The newborns in both groups were assessed with neurological
function, the NABA scores was recorded. Results: The level of NSE and S100B protein In serum in the treatment group and routin theray
group in 48h were no significantly difference （※P＞0.05，※P＞0.05）.As compared with control group it was significantly difference
（△P<0.05,△P<0.05）. The level of NSE and S-100B protein In serum after 10 days between two group were significantly difference, the
treatment group were significantly decreased (※P＜0.05，※P＜0.05). The NBNA score< 35 point after 3 weeks account for 27.0% in
treatment group and 53% in control group,which had significantly difference （x2＝6.112， ※ P<0.05). Conclusions: exogenous
phosphocreatine can protect brain tissure and improve the energetic metabolism of the brain cell , can lessen cerebral ischemic injury,
which can decrease disability rate and improve neurological function. |
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