| 张蕾1 王霞2 张珊3 杨彦华2△ 石纳玉3 蔡广彦3.ProEx C 在宫颈癌及其癌前病变中的表达及意义[J].现代生物医学进展英文版,2011,11(20):3878-3881. |
| ProEx C 在宫颈癌及其癌前病变中的表达及意义 |
| Expression and Significance of ProEx C in Cervical Cancer and CervicalIntraepithelial Noplasia |
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| DOI： |
| 中文关键词: 子宫颈癌 子宫颈癌前病变 ProEx C 组织芯片 免疫组化 |
| 英文关键词: Cervical cancer Cervical intraepithelial neoplasia ProEx C Tissue microarray Immunohistochemistry |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨ProEx C 在宫颈癌及其癌前病变中的表达及意义。方法：应用免疫组织化学SP 法检测ProEx C 在不同宫颈病变
组织芯片中的表达。结果：ProEx C 在宫颈炎、CINI 、CINII、CINIII 及宫颈癌中的阳性表达率分别是25%,51.7%，77.9%，90%，
93.8%，且其表达在宫颈癌及CINIII 级病变与宫颈炎及CINI 级病变相比较差异具有统计学意义(P＜0.05)，ProEx C 在CINI 级组
织中表达低于CINII 级，差异具有统计学意义(P＜0.05)，ProEx C 在浸润性宫颈癌中的表达与临床病理因素无关(P＞0.05)。结论：
ProEx C 反映了细胞的增殖活性，促进宫颈癌的发生发展，可作为诊断及监测预后的指标。 |
| 英文摘要: |
| Objective: To explore the expression and significance of ProEx C in cervical cancer and cervical intraepithelial
neoplasia. Methods: The expressions of ProEx C in the cervical tissue microarray were detected by immunohistochemical SP methods．
Results:The positive rate of ProEx C in chronic cervicitis, CINI, CINII, CINIII and cervical cancer were 25%,51.7%，77.9%，90%，93.8%
respectively. The expression levels of ProEx C in cervical cancer and CINIII were significantly higher than those in cervicitis and CINI
tissues（P＜0.05）. ProEx C expression was higher in CINII lesions than in CINI lesions（P＜0.05）.There were no significant differences
between ProEx C expressions and clinicopathologic factors （P＞0.05）. Conclusions: The expression of ProEx C reflect the proliferative
activity and it play an important role in the carcinogenesis of cervical cancer. Moreover it could be useful in diagnosing the degree of
cervical lesions and monitoring the prognosis . |
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