| 孙洁1 温进2 魏惠芳1 仲大奎3 曾霈君1 李滢1 杨磊1 张露芬1.电针不同穴位对慢性炎症痛模型大鼠心理行为改变的实验观察[J].现代生物医学进展英文版,2011,11(20):3820-3825. |
| 电针不同穴位对慢性炎症痛模型大鼠心理行为改变的实验观察 |
| Experimental Abservation on Psychological and Behavioral Changes byElectro-Acupuncture at Different Acupoints in Model Rats of ChronicInflammatory Pain |
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| DOI： |
| 中文关键词: 慢性炎症痛 电针 高架十字迷宫 |
| 英文关键词: Chronic inflammatory pain Electro-Acupuncture (EA) Elevated plus-maz |
| 基金项目: |
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| 中文摘要: |
| 目的：观察电针不同穴位对慢性炎症痛模型大鼠行为学改变的影响，进一步探讨电针对慢性痛所致心理行为改变的调节规
律。方法：将40 只雄性Wistar 大鼠随机分为正常组、模型组、电针百会组、电针关元组、电针足三里组，每组各8 只。除正常组外，
其余各组均采用弗氏完全佐剂（CFA）制备佐剂性关节炎（AA，即慢性炎症痛）大鼠模型，于造模第2 天各治疗组捆绑固定后给予
电针20 min，正常组及模型组捆绑束缚20 min，隔日一次，共10 次。于造模前、造模后、治疗5 次、10 次分别采用高架十字迷宫检
测各组大鼠开放臂进入次数比例(OE % )及开放臂停留时间比例(OT % )的变化。结果：与造模前比较，电针百会穴组大鼠造模后
OE %和OT %明显减少（P<0.05，P<0.05），且治疗5 次后OT %、治疗10 次后OE %与OT %均降低明显（P<0.01，P<0.01，P<0.05），
而电针关元组大鼠治疗10 次后OE %和OT %则明显升高（P<0.05，P<0.05），电针足三里组大鼠造模后OT%、治疗5 次后大鼠O
E %与OT %、治疗10 次后OT %均明显降低（P<0.01，P<0.05，P<0.01，P<0.05）；与造模刚结束比较，电针百会组大鼠在治疗5 次、
10 次后OE %由升高逐步降低，而OT %由低逐渐升高（P>0.05），电针关元组模型大鼠治疗10 次后模型大鼠OE %和OT %均明
显升高（P<0.05，P<0.05），电针足三里组模型大鼠治疗10 次后OT %升高明显（P<0.05）；与治疗5 次后比较，电针百会组大鼠在治
疗10 次后OE %降低、OT %升高（P>0.05），电针关元组与电针足三里组大鼠治疗10 次后OE % 和OT %均明显升高（P<0.05，
P<0.05；P<0.01，P<0.01）。与电针百会组比较，电针关元组与电针足三里组大鼠在治疗10 次时OE %均明显升高（P<0.01，P<0.01）。
结论：电针不同穴位具有一定抗抑郁和抗焦虑作用，可改善慢性炎症痛所致大鼠焦虑、情绪行为的变化；不同穴位效应不同，关元
穴与足三里穴具有综合调节、抗焦虑效应，且具有相对特异性。 |
| 英文摘要: |
| Objective: To investigate the effect of Electro-Acupuncture at different acupoints on behavioral changes caused by group increased after the 5th treatment and decreased gradually after the 10th treatment, while the OT % of that vice versa (P> 0.05), the
OE % and OT% of the rats in Guanyuan group increased significantly after the 10th treatment (P<0.05，P<0.05), the OT % of the rats in
Zusanli group increased significantly after the 10th treatment (P<0.05); Compared with that in the groups after the 5th treatment, The OE
% of rats in Baihui group decreased and The OT % increased after the 10th treatment (P>0.05),The OE % and OT % of rats in Guanyuan
group and Zusanli group all increased significantly after the 10th treatment (P<0.05, P<0.05; P<0.01，P<0.01). Compared with that in
Baihui group, the OE % of rats in Guanyuan group and Zusanli group significantly increased after the 10th treatment (P<0.01,P<0.01).
Conclusions: Electro-Acupuncture at different acupoints had some antidepressant and anxiolytic effects, which could improve anxiety and
changes in emotion and behavior induced by chronic inflammatory pain; The different acupoints had different effects, Guanyuan and
Zusanli having a comprehensive regulation and anxiolytic effect, which had relative specificity.
chronic inflammatory pain and to discuss the regulation rule of Electro-Acupuncture for psychological and behavioral changes caused by
chronic pain. Methods: The 40 male Wistar rats were randomly divided into the normal group, the model group, Baihui group, Guanyuan
group and Zusanli group, with 8 rats in each group. Except the normal group, the rest rats were used complete Freund adjuvant (CFA) to
make adjuvant arthritis (AA, that is chronic inflammatory pain) rat model. The 2nd day after model made, the normal group and the
model group were tied up for 20 min, and the treatment groups were used Electro-Acupuncture for 20 min, once every other day, a total
of 10 times. All rats were tested into the elevated plus-maze respectively to detect the changes of the proportion of the number of entry
into the open arms of the elevated plus-maze (OE %) and that of Residence time in the open arms (OT %) at four time points, including
before and after modeling, after the 5th treatment and 10th treatment. Results: Compared with that in the groups before modeling, the OE
% and OT % of the rats in Baihui group decreased significantly after modeling (P <0.05, P <0.05),and after the 5th treatment the OT % of
the rats、after the 10th treatment the OE % and OT % of the rats in Baihui group all decreased significantly (P<0.01,P<0.01,P<0.05), the
OE % and OT% of the rats in Guanyuan group increased significantly after the 10th treatment(P<0.05，P<0.05), after modeling the OT %
of the rats、after the 5th treatment the OE % and OT % of the rats、after the 10th treatment the OT % of the rats in Zusanli group all
decreased significantly (P<0.01,P<0.05,P<0.01,P<0.05); Compared with that in the groups after modeling, the OE % of the rats in Baihui |
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