| 赵妍白翠红.NDRG1 的功能及其与癌症的关系[J].现代生物医学进展英文版,2011,11(19):3798-3800. |
| NDRG1 的功能及其与癌症的关系 |
| The function of NDRG1 and its relationship with cancer |
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| DOI： |
| 中文关键词: NDRG1（N-myc 下游调节基因1） 缺氧 癌症 |
| 英文关键词: NDRG1 Hypoxia Cancer |
| 基金项目: |
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| 中文摘要: |
| 细胞生长、分化和多种应激的情况都可以影响NDRG1（N-myc downstream-regulated gene 1）蛋白的表达水平。NDRG1 在许
多细胞的正常生理功能中起着重要作用，NDRG1 的缺乏可能导致多种疾病，如4D 型CMTD(夏- 马- 图三氏病进行性神经性肌
萎缩，Charcot-Marie-Tooth disease)的发生与施万细胞中NDRG1 的缺失有关。在多种癌细胞系中，NDRG1 的转录和翻译与肿瘤的
分化和转移有关。在缺氧环境中，NDRG1 的表达水平上调，而且在许多肿瘤细胞中都存在缺氧的现象，这使得NDRG1 与缺氧和
癌症之间存在着复杂的关系。NDRG1 与癌症的关系使得NDRG1 可能作为肿瘤演进的标识和癌症诊断的辅助工具。 |
| 英文摘要: |
| The expression of NDRG1（N-myc downstream-regulated gene 1）protein is affected by cell growth, cell differentiation
and a wide variety of stress.NDRG1 plays an important role in the physiologic function of cells. The deficiency of NDRG1 may cause
many diseases. The probable cause of Charcot-Marie-Tooth type 4D disease is the deficiency of NDRG1 in Schwann cell. The transcription
and translation of NDRG1 correlate with cell differentiation and metastasis in various cancer cell lines. Because it is strongly up-regulated
under hypoxic condition, and this condition is prevalent in solid tumors, its regulation is a little complicated. NDRG1 gene may be
a marker of tumor progression and an efficient diagnostic tool in many types of cancers. |
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