欢迎访问《现代生物医学进展》编辑部！

目的：探讨血清孕酮与β-HCG 联合检测在预测早期先兆流产预后及其治疗的临床价值。方法：对340 例早期先兆流产患者血清P 与β-HCG 进行检测,并与追踪到的妊娠结局进行分析。结果：血清P 值>25 ng/ml、血β-HCG>50 mIU/ml 患者66 例占 19.4%,经绝对卧床休息,未用药治疗,均胚胎发育正常；血清P 值在15.94~25ng/ml、血β-HCG 10~50 mIU/ml 患者170 例占50%, 经口服黄体酮与HCG 针保胎治疗后均胚胎发育正常；血清P 值<15.94 ng/ml、血β-HCG<10mIU/ml 患者78 例占22.9%,终止妊娠者均可见清除宫内组织物中几乎不见新鲜绒毛并伴有不同程度的陈旧性出血；血清孕酮与β-HCG 上升不同步患者26 例占 7.6%,均最终难免流产。结论：联合检测血清孕酮与β-HCG 可以预测先兆流产患者妊娠结局,对于指导治疗具有重要的临床价值, 既避免不必要的药物干预及经济负担,又能起到提高保胎治疗的成功率。绒毛膜促性腺激素配伍口服天然黄体酮治疗由黄体功能不全引发的早期先兆流产，均能改善先兆流产患者的预后，且对母儿无不良影响，安全有效。

英文摘要:

Objective: To explore the clinical value of joint detection of serum progesterone and β-HCG in prediction of outcomes of early threatened abortion. Methods: The serum levels of progesterone and β-HCG in 340 cases with early threatened abortion were detected, then the pregnancy outcomes were analyzed. Results: There were 66 cases (19.4%) whose serum progesterone>25 ng/ml and β-HCG>50 mIU/ml, and the development of fetuses was normal after absolute bed rest and without drug treatment; there were 170 cases (50% ) with serum progesterone range within 15.94~25ng/ml and β-HCG range within 10~50 mIU/ml, and the development of fetuses was normal after treatment of progesterone and HCG; there were 78 cases (22.9%) whose serum progesterone<15.94 ng/ml and β -HCG<10 mIU/ml, and no fresh villi was found in removed intrauterine tissues of cases who terminated pregnancy with old hemorrhage at different degree; 26 cases were found with unsynchronized increase of serum progesterone and HCG, accounting for 7.6%, and finally abortion occurred. Conclusion: Joint detection of serum progesterone and β-HCG can predict the pregnancy outcomes of threatened abortion, which may play an important role in directing treatment, avoid unnecessary drug intervention and economic burden, and increase the success rate of tocolysis.

View Full Text View/Add Comment Download reader