| 韩伟1 刘杨2 齐蕾1 单丽辉1 柴翠翠1 王立峰1.胃癌组织中Tenascin、MVD、Ki-67 的表达及其临床意义[J].现代生物医学进展英文版,2011,11(19):3767-3770. |
| 胃癌组织中Tenascin、MVD、Ki-67 的表达及其临床意义 |
| Expression of Tenascin, MVD, Ki-67 in Gastric Adenocarcinoma and TheirClinical Significance |
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| DOI： |
| 中文关键词: 胃癌 Tenascin 微血管密度 Ki-67 免疫组织化学 |
| 英文关键词: Gastric Adenocarcinoma Tenascin Microvascular Density Ki-67 Immunohistochemistry |
| 基金项目:哈尔滨市科技创新人才专项资金项目（RC2010XK004048） |
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| 中文摘要: |
| 目的：探讨胃癌组织中Tenascin 蛋白、微血管密度（microvascular density, MVD）、Ki-67 的表达及其与临床病理特征的关系。
方法：采用免疫组化Elivision 法检测70 例胃癌组织和20 例癌旁正常组织中Tenascin、CD34 和Ki-67 的表达。结果：①正常胃黏
膜上皮Tenascin 阴性，胃癌中的Tenascin 主要表达于肿瘤相关纤维母细胞的胞质中，且与胃癌的Lauren 分型、分化程度、临床分
期、淋巴结转移显著相关（P＜0.05）；②胃癌中MVD 和Ki-67-LI（标记指数）均高于正常胃黏膜（P＜0.001），且均与胃癌的临床分
期、浸润深度、淋巴结转移显著相关（P＜0.05）；结论：胃癌组织中Tenascin 可抑制胃癌的演进，MVD 及Ki-67 可作为胃癌患者预
后的预测指标，联合检测胃癌组织Tenascin、MVD、Ki-67 的表达情况，对于进一步了解胃癌的生物学行为和判断预后具有一定的
临床价值与意义。 |
| 英文摘要: |
| Objective: To investgate the expression of Tenascin, microvascular density (MVD), Ki-67 in gastric carcinoma and
their relationship with clinicopathologic features. Methods: The expression of Tenascin, CD34 and Ki-67 in 70 cases of gastric carcinoma
and 20 cases of normal gastric tissue was detected by immunohistochemistry. Results:① Tenascin was mainly expressed in tumor associated
fibroblasts and the level of its expression was associated with Lauren classification, differentiation degree, TNM tumour stage
and lymph node metastases (P＜0.05);② The expression of MVD and Ki-67-LI was significantly higher in gastric cancer than in normal
gastric tissue (P＜0.001), both of them were respectively correlated with the TNM tumour stage, the depth of tumour invasion and lymph
node metastases (P＜0.05). Conclusions: Tenascin may inhibit the development of gastric cancer. Quantitation of MVD and Ki-67 were
useful prognostic marker for gastric cancer patients. Therefore, the detection of tenascin, MVD and Ki-67 may be valuable to evaluate
biological behavior for patients with gastric cancer during clinical treatment. |
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