| 高应东1 夏永祥1 张瑞生1 朱成宾1 赵昕亚1 肖平喜2.血浆IIA 分泌型磷脂酶A2 水平与冠脉支架术后再狭窄关系[J].现代生物医学进展英文版,2011,11(19):3666-3668. |
| 血浆IIA 分泌型磷脂酶A2 水平与冠脉支架术后再狭窄关系 |
| Relationship Between Plasma IIA Secretory Phospholipase A2 andRestenosis after Percutanous Coronary Intervention in Patients withCoronary Heart Disease |
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| DOI： |
| 中文关键词: ⅡA 分泌型磷脂酶A2 高敏C- 反应蛋白 支架植入术 再狭窄 |
| 英文关键词: Group IIA secretory phospholipase A2 High sensitive C-reactive protein Percutanous coronary intervention Restenosis |
| 基金项目: |
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| 中文摘要: |
| 目的：测定稳定型冠心病患者支架植入术（percutanous coronary intervention ,PCI）前血浆IIA 分泌型磷脂酶A2(group IIA
secretory phospholipase A2，ⅡA-sPLA2)的水平，以探讨该酶与冠脉支架术后再狭窄的可能关系。方法：稳定型冠心病行PCI 患者
63 例，非冠心病患者39 例，健康正常对照组42 例，分别取外周静脉血测定血浆ⅡA-sPLA2 酶浓度。PCI 患者6 个月后复查造影。
结果：PCI 患者术前该酶浓度显著高于正常对照组(P<0.05)，支架内再狭窄率34.9 %，再狭窄（restenosis，RS）患者支架术前该酶水
平与无再狭窄患者该酶水平无统计学差异（P>0.05）。结论：PCI 患者术前血浆ⅡA-sPLA2 酶浓度显著高于正常对照组，但可能与
支架术后再狭窄无关。 |
| 英文摘要: |
| Objective: To study the correlation between IIA-sPLA2 level and restenosis after percutanous coronary intervention
(PCI) in Patients with coronary heart disease. Methods: This study enrolled 63 patients with coronary heart disease (CHD) who underwent
successful PCI，39 patients with non-CHD, and 42 healthy subjects were studied as a control group .Levels of IIA-sPLA2 in plasma
were measured by an enzymoimmunoassay using a monoclonal antibody. The patients who underwent PCI had repeat angiography at
six-month follow-up. Results: The level of IIA-sPLA2 in PCI patients was significantly higher than that in healthy subjects (P<0.05), but
not higher than that in patients with non-CHD (P>0.05). Restenosis occurred in 22 patients (34.9 %). While there were no significantly
changes of the levels of IIA-sPLA2 between the patients without or with restenosis. Conclusions: The level of IIA-sPLA2 in patients with
coronary heart disease had a significant increase compared to the healthy subjects, but such increase may not be associated with in-stent
restenosis. |
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