| 耿怀成1 王冰蝉2 陈薇薇1 胡成如1.胰岛素样生长因子-1 受体(IGF-IR)在乳腺癌组织中的表达及其
临床意义初探[J].现代生物医学进展英文版,2011,11(19):3625-3628. |
| 胰岛素样生长因子-1 受体(IGF-IR)在乳腺癌组织中的表达及其
临床意义初探 |
| Expression of Insulin-Like Growth Factor-1 Receptor mRNA in HumanBreast Cancer Tissues and Its Clinical Significance |
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| DOI： |
| 中文关键词: 乳腺癌 胰岛素样生长因子-1 受体 RT-PCR 预后 |
| 英文关键词: Breast cancer Insulin-like growth factor-I receptor RT-PCR Prognosis |
| 基金项目: |
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| 中文摘要: |
| 目的：检测分析胰岛素样生长因子-1 受体(IGF-IR)在乳腺癌组织中的表达状况及其临床意义。方法：应用半运用半定量
RT-PCR 方法分析84 例乳腺癌和癌旁正常乳腺组织中IGF-1R 基因mRNA 的表达水平，并分析其表达与患者临床病理特征及预
后之间的关系。结果：乳腺癌组织中IGF-1R 基因mRNA 表达水平显著高于癌旁乳腺组织，二者具有统计学差别(P<0.001)。乳腺癌
组织中IGF-1R 基因mRNA 表达水平与肿瘤组织分化程度及乳腺癌患者的TNM 分期和淋巴结转移情况显著相关(P 值分别是
0.005，0.025 和0.041)。另外，高表达IGF-1R 的乳腺癌患者的五年总体生存率(38.3%)显著高于低表达IGF-1R 的患者(49.7%; P=0.
009)。多因素COX 模型分析结果表明：IGF-1R 基因mRNA 表达水平是乳腺癌患者的一个独立预后分子(HR=2.78，95%CI:
1.94-3.94，P=0.041)。结论：IGF-1R 基因表达水平上调在乳腺癌发展过程中起着重要的作用。IGF-1R 基因mRNA 表达水平有望成
为临床乳腺癌患者预后判断的一个重要分子标志物。 |
| 英文摘要: |
| Objective: To investigate the expression of IGF-1R mRNA in human breast cancer tissues and its prognostic roles.
Methods: Semi-quantitative RT-PCR assay was employed to detect the expression of IGF-1R mRNA in 82 breast cancer and corresponding
normal breast epithelial tissues. Additionally, the correlation of IGF-1R mRNA expression with clinicopathological factors of breast
cancer patients was investigated and its correlation with prognosis of breast cancer patients was also investigated. Results: The level of
IGF-1R mRNA expression was significantly higher than that in corresponding normal breast epithelial tissues (P<0.001). High level of
IGF-1R mRNA expression was significantly correlated with tumor differentiation, TNM stage and lymph node metastasis of breast cancer
patients (P=0.005, 0.025 and 0.041, respectively). The 5-year overall survival rate of breast cancer patients with high IGF-1R mRNA
(38.3%) was significantly shorter than that in those patients with low IGF-1R mRNA (49.7%; P=0.009). Multivariate analysis of COX
model showed that IGF-1R mRNA expression was an independent prognostic factor for breast cancer patients (HR=2.78，95% CI:
1.94-3.94，P=0.041). Conclusion: The upregulation of IGF-1R mRNA might play important roles in progression of breast cancer and the
status of IGF-1R mRNA expression has potential of being an important biomarker for breast cancer patients. |
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