| 周霞况雪梅汤影之邓国宏王宇明.乙型肝炎病毒RT 区变异及其与基因型分布的关系[J].现代生物医学进展英文版,2011,11(19):3605-3609. |
| 乙型肝炎病毒RT 区变异及其与基因型分布的关系 |
| Mutation in the RT Region of Hepatitis B Virus and Its Relationshipwith HBV Genotypes Distribution |
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| DOI： |
| 中文关键词: 乙型肝炎 基因型 突变 RT 区 |
| 英文关键词: Hepatitis B Genotype Mutation RT region |
| 基金项目:国家自然科学基金重点项目（2008ZX10002-007） |
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| 中文摘要: |
| 目的：探讨大样本乙型肝炎病毒（HBV）感染患者RT 区耐药位点变异的流行情况，及各耐药位点变异与HBV 基因型的关
系。方法：采用P 区测序法对1117 例慢性乙型肝炎患者的血清病毒进行P 区测序、进化树分型。结果：RT 区耐药位点变异发生率
与基因型关系密切，在基因型C 患者中的变异发生率远远高于基因型B 患者（P=0.000）。Rt180、rtM204V、rtM204I、rt181、rt213 位
点变异均与基因型C 有关（P＜0.05）。主要的三种变异类型rt180+rtM204V、rtM204I、rt180+rtM204I 间基因型分布存在显著差异
（P=0.003）。不同HBeAg 状态下，耐药变异的发生有显著差异（P=0.020），特别是rt181 和rt236 位点变异。结论：HBV 基因型影响
RT 区耐药变异发生率及变异类型，且耐药变异发生率也与HBeAg 状态有关。 |
| 英文摘要: |
| Objective: To investigate the prevalence of resistance mutations in the RT region in a large sample of patients with
hepatitis B virus (HBV), and the relationship between resistance mutation and HBV genotypes. Methods: RT region of HBV gene in
1117 patients was sequenced and HBV genotypes were analyzed by phylogenetic tree. Results: The resistance mutation rate in the RT region
was closely related to HBV genotypes, and it was obviously higher in genotype C than in genotype B (P=0.000). The variation of
rt180, rtM204V, rtM204I, rt181, rt213 position was related with genotype C (P<0.05). The distribution of HBV genotypes in three major
types of variation, rt180+rtM204V, rtM204I, rt180+rtM204I, was obviously different (P=0.003). HBeAg is relevant to the originate of
drug resistance mutation (P = 0.020), especially rt181 and rt236 position. Conclusions: HBV genotypes influenced the incidence and
types of resistance variation in RT region, and resistance variation incidence was also related to HBeAg state. |
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