| 张志华李坚.围绝经期综合症治疗进展[J].现代生物医学进展英文版,2011,11(18):3580-3582. |
| 围绝经期综合症治疗进展 |
| Treatment of Perimenopausal Syndrome |
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| DOI： |
| 中文关键词: 围绝经期综合症 黑升麻类药物 5-HT |
| 英文关键词: Perimenopausal symptoms Black cohosh 5-HT |
| 基金项目: |
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| 中文摘要: |
| 女性一生中大约有l／3 的时间是在绝经后度过的，围绝经期症状使得女性的日常生活及工作受到了很大的影响。传统的治
疗方法为激素替代治疗，但因可能会增加乳癌和子宫内膜癌等的发病风险，其应用还存在很大的争议，非激素类药物包括中枢肾
上腺素受体激动剂，选择性的5-HT 重摄取抑制剂，γ- 氨基丁酸类似物，黑升麻类药物等。黑升麻类药物缓解围绝经期症状的疗
效是肯定的，黑升麻没有雌激素样作用，可能是通过5- 羟色胺受体来发挥作用的。 |
| 英文摘要: |
| Postmenopausal days account 1/3 of the whole time of women's lives. Their daily life and work are affected heavily by
menopausal symptoms. Traditional treatment is hormone replacement therapy which is controversial, because it may increase the risk of
breast cancer and endometrial cancer. Non-hormonal drugs include Clonidine, a selective 5-HT reuptake inhibitors, γ-aminobutyric acid
analogues, black cohosh drugs. Black cohosh drugs can effectively alleviate menopause symptoms. Recently researches discovered this
type of drugs has not estrogenic activity. The effect of Black cohosh may be involved in 5-HT receptors. |
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