| 皮精英1 陈超霞2 彭强2 彭大川2 李宜静2.子宫内膜癌患者P16 基因甲基化和血清CA125 检测的临床意义[J].现代生物医学进展英文版,2011,11(18):3550-3552. |
| 子宫内膜癌患者P16 基因甲基化和血清CA125 检测的临床意义 |
| Clinical Significance of P16 Gene Methylation and Blood Serum CA125Examination in Patients with Endometrium Cancer |
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| DOI： |
| 中文关键词: 子宫内膜癌 基因,p16 基因表达；CA125 |
| 英文关键词: Endometrium cancer Gene, p16 Gene expression CA125 |
| 基金项目: |
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| 中文摘要: |
| 目的：探讨子宫内膜癌患者P16 基因甲基化和血清CA125 检测的临床意义。方法：采用DNA 甲基化特异性PCR 分别对46
例子宫内膜癌及12 例正常内膜对照组织中抑癌基因p16 甲基化进行检测;对所有病例术前均测定血清CA125 水平。结果：子宫
内膜癌组p16 甲基化率45.6%，而12 例对照组织均未检测到甲基化；子宫内膜癌组血清CA125 水平明显升高。结论：子宫内膜癌
患者p16 基因甲基化和血清CA125 水平与发病关系密切，两者结合对早期诊断及预后判断具有一定的临床指导意义。 |
| 英文摘要: |
| Objective: To investigate endometrial cancer P16 gene methylation and the clinical significance of serum CA125.
Methods: The detection of 46 cases of endometrial cancer and 12 normal endometrial tissue in the tumor suppressor gene p16 DNA
methylation using methylation-specific PCR; in all cases before surgery were serum CA125 level. Results: Endometrial cancer group
45.6% rate of p16 methylation, while 12 cases were not detected in control tissue methylation; serum CA125 levels were significantly
increased in endometrial cancer group. Conclusion: The endometrium cancer patient p16 gene methylation and the blood serum CA125
level morbidity relations are close, Both union has certain clinical guiding sense to the early diagnosis and the prognosis judgment. |
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